Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion
Φόρτωση...
Ημερομηνία
Συγγραφείς
Varla-Leftherioti, M.
Spyropoulou-Vlachou, M.
Keramitsoglou, T.
Papadimitropoulos, M.
Tsekoura, C.
Graphou, O.
Papadopoulou, C.
Gerondi, M.
Stavropoulos-Giokas, C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Hum Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Previous studies have revealed that women with unexplained recurrent spontaneous abortions have a limited repertoire of inhibitory KI receptors (inhKIRs) and that the inhKIRs they possess do not have specificity for the human leukocyte antigen (HLA)-Cw molecules that would be expressed on trophoblast. We sought to confirm these findings by direct definition of maternal inhKIR and trophoblastic HLA-Cw allotypes on the placental material of spontaneously missed pregnancies. The study included 30 women undergoing vacuum uterine curettage for first-trimester missed pregnancy (group A; n = 15) or for elective termination of normal pregnancy (group C, n = 15). DNA extracted from isolated decidual and trophoblastic cells was used for molecular detection of maternal inhKIRs (2DL1, 2DL2, 2DL3) and fetal HLA-Cw alleles, respectively. The results revealed that in the group of women who experienced abortion, 60% did not have the full repertoire of three inhKIRs (group A vs group C; p = 0.006); that in five of 15 patients (none in the controls), no epitope matching existed between maternal inhKIRs and trophoblastic HLA-Cw alleles (group A vs group C; p = 0.01); and that more cases were found with limited epitope matching (less than three inhKIRs with specificity for fetal HLA-Cw alleles). The results provide additional evidence that in some cases of spontaneous abortions, the women lack the appropriate inhKIRs to interact with the HLA-Cw molecules on trophoblasts and to deliver signals to inhibit natural killer cell activation and protect the embryo.
Περιγραφή
Λέξεις-κλειδιά
Abortion, Spontaneous/*immunology, Decidua/immunology, Female, HLA-C Antigens/*immunology, Humans, Killer Cells, Natural/*immunology, Lymphocyte Activation/immunology, Placenta/immunology, Pregnancy, Receptors, Immunologic/*immunology, Trophoblasts/*immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15620464
http://ac.els-cdn.com/S0198885904006494/1-s2.0-S0198885904006494-main.pdf?_tid=7aa4e337b55430714ae11f3b444454b7&acdnat=1332847426_dc568bea14999400529abeab450b0d56
http://ac.els-cdn.com/S0198885904006494/1-s2.0-S0198885904006494-main.pdf?_tid=7aa4e337b55430714ae11f3b444454b7&acdnat=1332847426_dc568bea14999400529abeab450b0d56
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής