Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion

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dc.contributor.authorVarla-Leftherioti, M.en
dc.contributor.authorSpyropoulou-Vlachou, M.en
dc.contributor.authorKeramitsoglou, T.en
dc.contributor.authorPapadimitropoulos, M.en
dc.contributor.authorTsekoura, C.en
dc.contributor.authorGraphou, O.en
dc.contributor.authorPapadopoulou, C.en
dc.contributor.authorGerondi, M.en
dc.contributor.authorStavropoulos-Giokas, C.en
dc.date.accessioned2015-11-24T19:08:18Z
dc.date.available2015-11-24T19:08:18Z
dc.identifier.issn0198-8859-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20515
dc.rightsDefault Licence-
dc.subjectAbortion, Spontaneous/*immunologyen
dc.subjectDecidua/immunologyen
dc.subjectFemaleen
dc.subjectHLA-C Antigens/*immunologyen
dc.subjectHumansen
dc.subjectKiller Cells, Natural/*immunologyen
dc.subjectLymphocyte Activation/immunologyen
dc.subjectPlacenta/immunologyen
dc.subjectPregnancyen
dc.subjectReceptors, Immunologic/*immunologyen
dc.subjectTrophoblasts/*immunologyen
dc.titleLack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortionen
heal.abstractPrevious studies have revealed that women with unexplained recurrent spontaneous abortions have a limited repertoire of inhibitory KI receptors (inhKIRs) and that the inhKIRs they possess do not have specificity for the human leukocyte antigen (HLA)-Cw molecules that would be expressed on trophoblast. We sought to confirm these findings by direct definition of maternal inhKIR and trophoblastic HLA-Cw allotypes on the placental material of spontaneously missed pregnancies. The study included 30 women undergoing vacuum uterine curettage for first-trimester missed pregnancy (group A; n = 15) or for elective termination of normal pregnancy (group C, n = 15). DNA extracted from isolated decidual and trophoblastic cells was used for molecular detection of maternal inhKIRs (2DL1, 2DL2, 2DL3) and fetal HLA-Cw alleles, respectively. The results revealed that in the group of women who experienced abortion, 60% did not have the full repertoire of three inhKIRs (group A vs group C; p = 0.006); that in five of 15 patients (none in the controls), no epitope matching existed between maternal inhKIRs and trophoblastic HLA-Cw alleles (group A vs group C; p = 0.01); and that more cases were found with limited epitope matching (less than three inhKIRs with specificity for fetal HLA-Cw alleles). The results provide additional evidence that in some cases of spontaneous abortions, the women lack the appropriate inhKIRs to interact with the HLA-Cw molecules on trophoblasts and to deliver signals to inhibit natural killer cell activation and protect the embryo.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.humimm.2004.10.005-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15620464-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0198885904006494/1-s2.0-S0198885904006494-main.pdf?_tid=7aa4e337b55430714ae11f3b444454b7&acdnat=1332847426_dc568bea14999400529abeab450b0d56-
heal.journalNameHum Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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