Gender differences in the lipid profile of dyslipidemic subjects
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Authors
Kolovou, G. D.
Anagnostopoulou, K. K.
Damaskos, D. S.
Bilianou, H. I.
Mihas, C.
Milionis, H. J.
Kostakou, P. M.
Cokkinos, D. V.
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Abstract
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peer-reviewed
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Eur J Intern Med
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OBJECTIVE: We evaluated the gender-associated differences in lipid profile of subjects intended to receive lipid-lowering therapy with emphasis on the associations between triglycerides (TG) and other plasma lipid variables. DESIGN: Lipid profiles of 1385 patients [aged 55+/-11 years, 549 women (40%)] were evaluated. Eligible subjects fulfilled one or more of the following criteria: total cholesterol (TC)>or=6.2 mmol/l, TG>or=1.7 mmol/l, and high-density lipoprotein cholesterol (HDL-C)<1.0 mmol/l. Patients were divided into subgroups according to TG and HDL-C levels. RESULTS: Women aged on average 3.5 years older, had higher TC and HDL-C, lower TG and a correspondingly lower TC/HDL-C ratio than men. High TG and low HDL-C in tandem appeared twice more frequently in men. Inverse correlations between HDL-C and TG levels were found to exist in the entire cohort (r=-0.354, p<0.001) and in all various subgroups. In the subgroup with TG<1.7 mmol/l, women had higher TC and HDL-C, lower TG levels and lower TC/HDL-C ratio compared with men. In the subgroup with TG>or=1.7 mmol/l, women had higher TC and HDL-C levels and lower TC/HDL ratio compared with men. In the subgroup with HDL-C>or=1.0 mmol/l women had higher HDL-C, lower TG levels and lower TC/HDL-C ratio compared with men. CONCLUSIONS: Elevated TG levels and low HDL-C in tandem are common lipid abnormalities in the clinical setting of primary and secondary preventions. Gender-associated differences in the lipid profile are evident in subjects presenting with dyslipidemia and might be of potential relevance for diagnostics and therapy for the prevention of atherosclerosis.
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Keywords
Aged, Atherosclerosis/blood/epidemiology, Cholesterol, HDL/*blood, Cholesterol, LDL/blood, Dyslipidemias/*blood/*epidemiology, Female, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Risk Factors, *Sex Characteristics, Sex Distribution, Triglycerides/*blood
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http://www.ncbi.nlm.nih.gov/pubmed/19327602
http://ac.els-cdn.com/S0953620508001957/1-s2.0-S0953620508001957-main.pdf?_tid=34912c5e965b4e86a5f53559963ebe25&acdnat=1333950190_3c88c6115d010c2e87e5516109266792
http://ac.els-cdn.com/S0953620508001957/1-s2.0-S0953620508001957-main.pdf?_tid=34912c5e965b4e86a5f53559963ebe25&acdnat=1333950190_3c88c6115d010c2e87e5516109266792
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής