Gender differences in the lipid profile of dyslipidemic subjects

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dc.contributor.authorKolovou, G. D.en
dc.contributor.authorAnagnostopoulou, K. K.en
dc.contributor.authorDamaskos, D. S.en
dc.contributor.authorBilianou, H. I.en
dc.contributor.authorMihas, C.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorKostakou, P. M.en
dc.contributor.authorCokkinos, D. V.en
dc.date.accessioned2015-11-24T19:15:04Z
dc.date.available2015-11-24T19:15:04Z
dc.identifier.issn1879-0828-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21448
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAtherosclerosis/blood/epidemiologyen
dc.subjectCholesterol, HDL/*blooden
dc.subjectCholesterol, LDL/blooden
dc.subjectDyslipidemias/*blood/*epidemiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMultivariate Analysisen
dc.subjectRisk Factorsen
dc.subject*Sex Characteristicsen
dc.subjectSex Distributionen
dc.subjectTriglycerides/*blooden
dc.titleGender differences in the lipid profile of dyslipidemic subjectsen
heal.abstractOBJECTIVE: We evaluated the gender-associated differences in lipid profile of subjects intended to receive lipid-lowering therapy with emphasis on the associations between triglycerides (TG) and other plasma lipid variables. DESIGN: Lipid profiles of 1385 patients [aged 55+/-11 years, 549 women (40%)] were evaluated. Eligible subjects fulfilled one or more of the following criteria: total cholesterol (TC)>or=6.2 mmol/l, TG>or=1.7 mmol/l, and high-density lipoprotein cholesterol (HDL-C)<1.0 mmol/l. Patients were divided into subgroups according to TG and HDL-C levels. RESULTS: Women aged on average 3.5 years older, had higher TC and HDL-C, lower TG and a correspondingly lower TC/HDL-C ratio than men. High TG and low HDL-C in tandem appeared twice more frequently in men. Inverse correlations between HDL-C and TG levels were found to exist in the entire cohort (r=-0.354, p<0.001) and in all various subgroups. In the subgroup with TG<1.7 mmol/l, women had higher TC and HDL-C, lower TG levels and lower TC/HDL-C ratio compared with men. In the subgroup with TG>or=1.7 mmol/l, women had higher TC and HDL-C levels and lower TC/HDL ratio compared with men. In the subgroup with HDL-C>or=1.0 mmol/l women had higher HDL-C, lower TG levels and lower TC/HDL-C ratio compared with men. CONCLUSIONS: Elevated TG levels and low HDL-C in tandem are common lipid abnormalities in the clinical setting of primary and secondary preventions. Gender-associated differences in the lipid profile are evident in subjects presenting with dyslipidemia and might be of potential relevance for diagnostics and therapy for the prevention of atherosclerosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejim.2008.06.011-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19327602-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0953620508001957/1-s2.0-S0953620508001957-main.pdf?_tid=34912c5e965b4e86a5f53559963ebe25&acdnat=1333950190_3c88c6115d010c2e87e5516109266792-
heal.journalNameEur J Intern Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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