Endothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Baltogiannis, G. G.
Tsalikakis, D. G.
Mitsi, A. C.
Hatzistergos, K. E.
Elaiopoulos, D.
Fotiadis, D. I.
Kyriakides, Z. S.
Kolettis, T. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cardiovasc Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objective: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia, (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-I receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI. Methods: Thirty-five Wistar rats (223 +/- 22 g) were randomly allocated to either the ET-I receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI. Results: There were 15.94 +/- 19.35 episodes/h/rat of VT/VF in the control group and 1.66 +/- 2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40 +/- 7.16 s for the control group and 2.30 +/- 1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 It post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group. Conclusion: Acute ETA blockade reduces the incidence of VT/VF during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
arrhythmia (mechanisms), endothelins, infarction, coronary-artery occlusion, endogenous endothelin, ischemic arrhythmias, anesthetized rats, antagonist, heart, reperfusion, bq-123, size, dogs
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000231183500011
http://cardiovascres.oxfordjournals.org/content/67/4/647.full.pdf
http://cardiovascres.oxfordjournals.org/content/67/4/647.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικών