Endothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in rats

Απλή σελίδα τεκμηρίου
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorTsalikakis, D. G.en
dc.contributor.authorMitsi, A. C.en
dc.contributor.authorHatzistergos, K. E.en
dc.contributor.authorElaiopoulos, D.en
dc.contributor.authorFotiadis, D. I.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorKolettis, T. M.en
dc.date.accessioned2015-11-24T17:33:57Z
dc.date.available2015-11-24T17:33:57Z
dc.identifier.issn0008-6363-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/13913
dc.rightsDefault Licence-
dc.subjectarrhythmia (mechanisms)en
dc.subjectendothelinsen
dc.subjectinfarctionen
dc.subjectcoronary-artery occlusionen
dc.subjectendogenous endothelinen
dc.subjectischemic arrhythmiasen
dc.subjectanesthetized ratsen
dc.subjectantagonisten
dc.subjecthearten
dc.subjectreperfusionen
dc.subjectbq-123en
dc.subjectsizeen
dc.subjectdogsen
dc.titleEndothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in ratsen
heal.abstractObjective: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia, (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-I receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI. Methods: Thirty-five Wistar rats (223 +/- 22 g) were randomly allocated to either the ET-I receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI. Results: There were 15.94 +/- 19.35 episodes/h/rat of VT/VF in the control group and 1.66 +/- 2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40 +/- 7.16 s for the control group and 2.30 +/- 1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 It post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group. Conclusion: Acute ETA blockade reduces the incidence of VT/VF during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.cardiores.2005.04.020-
heal.identifier.secondary<Go to ISI>://000231183500011-
heal.identifier.secondaryhttp://cardiovascres.oxfordjournals.org/content/67/4/647.full.pdf-
heal.journalNameCardiovasc Resen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)