Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bai, M.
Papoudou-Bai, A.
Horianopoulos, N.
Grepi, C.
Agnantis, N. J.
Kanavaros, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Hum Pathol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The expression of various bcl2 family proteins has been reported in Hodgkin and Reed-Sternberg cells, but the proteins bad, bid, and bim have not been analyzed in classical Hodgkin's lymphomas (HLs). This study aimed to investigate the expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, bim, and active caspase 3, and the TUNEL (terminal deoxynucleotidyl transferase-mediated in situ labeling) index to gain further insight into the apoptosis profile of classical HLs. A high expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, and bim in HRS cells was found in 27 of 101 (27%), 95 of 101 (94%), 27 of 97 (29%), 73 of 95 (77%), 37 of 102 (36%), 85 of 94 (90%), 19 of 109 (17%), and 43 of 91 (47%) cases, respectively. The high expression of bcl-xl, bax, and bad in HRS cells in most classical HLs indicates that these proteins may play predominant roles in the regulation of apoptosis in classical HLs. Active caspase 3-positive and TUNEL-positive Reed-Sternberg cells were detected in 47 of 70 (67%; range, 0%-12%) and 60 of 71 (85%; range, 0%-19%) cases, respectively. Significant positive correlations were found between bax/bcl2 (P = .002), bad/bcl2 (P = .020), bad/bcl-xl (P = .003), and bim/mcl1 (P = .036). Based on these findings, it could be hypothesized that the antiapoptotic proteins bcl2, bcl-xl, and mcl1 may counteract the expression of the proapoptotic proteins bax, bad, and bim, thereby contributing to the survival of Reed-Sternberg cells.
Περιγραφή
Λέξεις-κλειδιά
Apoptosis/physiology, Apoptosis Regulatory Proteins/analysis, BH3 Interacting Domain Death Agonist Protein/analysis, Caspase 3/*biosynthesis, Hodgkin Disease/metabolism/*pathology/physiopathology, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Membrane Proteins/analysis, Neoplasm Proteins/analysis, Proto-Oncogene Proteins/analysis, Proto-Oncogene Proteins c-bcl-2/analysis/*biosynthesis, Reed-Sternberg Cells/chemistry/pathology, bcl-2 Homologous Antagonist-Killer Protein/analysis, bcl-2-Associated X Protein/analysis, bcl-Associated Death Protein/analysis, bcl-X Protein/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16949642
http://ac.els-cdn.com/S0046817706003819/1-s2.0-S0046817706003819-main.pdf?_tid=3c1c9c0cd8fb13f1f42772630c6efcda&acdnat=1333090453_abb24f491fa1b0ff07369356b7d16776
http://ac.els-cdn.com/S0046817706003819/1-s2.0-S0046817706003819-main.pdf?_tid=3c1c9c0cd8fb13f1f42772630c6efcda&acdnat=1333090453_abb24f491fa1b0ff07369356b7d16776
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής