Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas

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dc.contributor.authorBai, M.en
dc.contributor.authorPapoudou-Bai, A.en
dc.contributor.authorHorianopoulos, N.en
dc.contributor.authorGrepi, C.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:16:49Z
dc.date.available2015-11-24T19:16:49Z
dc.identifier.issn0046-8177-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21711
dc.rightsDefault Licence-
dc.subjectApoptosis/physiologyen
dc.subjectApoptosis Regulatory Proteins/analysisen
dc.subjectBH3 Interacting Domain Death Agonist Protein/analysisen
dc.subjectCaspase 3/*biosynthesisen
dc.subjectHodgkin Disease/metabolism/*pathology/physiopathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIn Situ Nick-End Labelingen
dc.subjectMembrane Proteins/analysisen
dc.subjectNeoplasm Proteins/analysisen
dc.subjectProto-Oncogene Proteins/analysisen
dc.subjectProto-Oncogene Proteins c-bcl-2/analysis/*biosynthesisen
dc.subjectReed-Sternberg Cells/chemistry/pathologyen
dc.subjectbcl-2 Homologous Antagonist-Killer Protein/analysisen
dc.subjectbcl-2-Associated X Protein/analysisen
dc.subjectbcl-Associated Death Protein/analysisen
dc.subjectbcl-X Protein/analysisen
dc.titleExpression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomasen
heal.abstractThe expression of various bcl2 family proteins has been reported in Hodgkin and Reed-Sternberg cells, but the proteins bad, bid, and bim have not been analyzed in classical Hodgkin's lymphomas (HLs). This study aimed to investigate the expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, bim, and active caspase 3, and the TUNEL (terminal deoxynucleotidyl transferase-mediated in situ labeling) index to gain further insight into the apoptosis profile of classical HLs. A high expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, and bim in HRS cells was found in 27 of 101 (27%), 95 of 101 (94%), 27 of 97 (29%), 73 of 95 (77%), 37 of 102 (36%), 85 of 94 (90%), 19 of 109 (17%), and 43 of 91 (47%) cases, respectively. The high expression of bcl-xl, bax, and bad in HRS cells in most classical HLs indicates that these proteins may play predominant roles in the regulation of apoptosis in classical HLs. Active caspase 3-positive and TUNEL-positive Reed-Sternberg cells were detected in 47 of 70 (67%; range, 0%-12%) and 60 of 71 (85%; range, 0%-19%) cases, respectively. Significant positive correlations were found between bax/bcl2 (P = .002), bad/bcl2 (P = .020), bad/bcl-xl (P = .003), and bim/mcl1 (P = .036). Based on these findings, it could be hypothesized that the antiapoptotic proteins bcl2, bcl-xl, and mcl1 may counteract the expression of the proapoptotic proteins bax, bad, and bim, thereby contributing to the survival of Reed-Sternberg cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.humpath.2006.06.017-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16949642-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0046817706003819/1-s2.0-S0046817706003819-main.pdf?_tid=3c1c9c0cd8fb13f1f42772630c6efcda&acdnat=1333090453_abb24f491fa1b0ff07369356b7d16776-
heal.journalNameHum Patholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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