Acute lung injury in a rat model of intestinal ischemia-reperfusion: The potential time depended role of phospholipases A(2)

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dc.contributor.authorKostopanagiotou, G.en
dc.contributor.authorAvgerinos, E.en
dc.contributor.authorCostopanagiotou, C.en
dc.contributor.authorArkadopoulos, N.en
dc.contributor.authorAndreadou, I.en
dc.contributor.authorDiamantopoulou, K.en
dc.contributor.authorLekka, M.en
dc.contributor.authorSmyrniotis, V.en
dc.contributor.authorNakos, G.en
dc.date.accessioned2015-11-24T16:43:08Z
dc.date.available2015-11-24T16:43:08Z
dc.identifier.issn0022-4804-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8655
dc.rightsDefault Licence-
dc.subjectintestinal ischemia-reperfusionen
dc.subjectacute respiratory distress syndromeen
dc.subjectacute lung injuryen
dc.subjectphospholipase a(2)en
dc.subjectplatelet-activating factoren
dc.subjectplatelet-activating factor acetylhydrolaseen
dc.subjectplatelet-activating-factoren
dc.subjectrespiratory-distress-syndromeen
dc.subjectbronchoalveolar lavage fluiden
dc.subjectfactor acetylhydrolaseen
dc.subjectclinical-trialen
dc.subjectorgan failureen
dc.subjectsevere sepsisen
dc.subjectpafen
dc.subjectmulticenteren
dc.subjectinhibitionen
dc.titleAcute lung injury in a rat model of intestinal ischemia-reperfusion: The potential time depended role of phospholipases A(2)en
heal.abstractBackground. A pivotal role of phospholipase A (PLA(2)) and platelet-activating factor-acetylhydrolase (PAF-AcH) as enzymes involved in lung inflammation has recently been suggested. The objective of this study was to elucidate the role and the time dependence of PLA(2) and PAF-AcH fluctuations in the lung relative to the evolution of intestinal ischemia-reperfusion (IIR). Materials and methods. Rats were randomly allocated to five groups of IIR induced by occlusion of the superior mesenteric artery for 45 min followed by 1 min, 2, 4, and 8 h of reperfusion (expGroups) and five corresponding sham groups (sGroups). Bronchoalveolar lavage fluid was obtained from the right lung and its biochemical (protein, PLA(2), PAF-AcH) and cytological characteristics were determined. Plasma malonyldialdehyde was measured as a marker of lipid peroxidation. The 4 and 8 h reperfusion expGroups had significantly (P < 0.05) elevated alveolar-arterial O-2 gradient values compared with the corresponding controls. Total protein, PLA2 and PAF-AcH levels significantly (P < 0.05) increased in expGroups compared with the corresponding shams after 4 h of reperfusion. Total bronchoalveolar lavage fluid cells and plasma malonyldialdehyde were significantly (P < 0.05) elevated in expGroups compared with the sGroups after 2 h of reperfusion. Conclusions. PIA could act synergistically or parallel with the reactive oxygen species produced during IIR, resulting in the induction or even in the exacerbation of the inflammatory reaction in acute respiratory distress syndrome. PAF-AcH could play an anti-inflammatory role by reducing the concentration of PAF. (C) 2008 Elsevier Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jss.2007.07.023-
heal.identifier.secondary<Go to ISI>://000255668500016-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0022480407004842/1-s2.0-S0022480407004842-main.pdf?_tid=4183b8fc5cce4ceebc14667d60a2de7c&acdnat=1333033713_0deeed6f5a06b8c44fac572c1c816d69-
heal.journalNameJournal of Surgical Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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