Tumor markers in stage P1 bladder cancer
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Authors
Stavropoulos, N. E.
Ioachim, E.
Charchanti, A.
Michael, M. C.
Kitsiou, E.
Mihailidis, I.
Hastazeris, K.
Agnantis, N. J.
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peer-reviewed
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Anticancer Res
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BACKGROUND: The infiltration of muscularis mucosa in superficial bladder cancer has been reported to be predictive of an unfavourable course of the disease. MATERIALS AND METHODS: We studied immunohistochemically Ki-67, PCNA and p53 tumour markers in 68 P1a and Pib bladder tumours. RESULTS: A statistically significant difference (p = 0.01) was found in the distribution of grades between stages P1a and P1b, with more grade 3 and less grade 2 tumours in the latter category. Univariate analysis revealed a strong association of Ki-67 (p = 0.001) and PCNA (p = 0.032) only with stage. P53 protein expression did not have any significant association with either stage or grade. In 60 patients entered into the multivariate analysis a clearly predominant, significant effect of stage on Ki-67 (p = 0.000) was shown. CONCLUSION: Increased proliferative activity when compared to P1a is present in P1b bladder tumours, as detected by the increased expression of Ki-67 proliferating antigen. The immunohistochemical study of Ki-67 antigen may help in predicting stage P1 tumours' behaviour, even in cases where pathological distinction of P1a and P1b substages is difficult.
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Keywords
Humans, Ki-67 Antigen/*analysis, Neoplasm Staging, Proliferating Cell Nuclear Antigen/*analysis, Tumor Markers, Biological/*analysis, Tumor Suppressor Protein p53/*analysis, Urinary Bladder Neoplasms/*chemistry/pathology
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http://www.ncbi.nlm.nih.gov/pubmed/11396238
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής