Tumor markers in stage P1 bladder cancer
| dc.contributor.author | Stavropoulos, N. E. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Charchanti, A. | en |
| dc.contributor.author | Michael, M. C. | en |
| dc.contributor.author | Kitsiou, E. | en |
| dc.contributor.author | Mihailidis, I. | en |
| dc.contributor.author | Hastazeris, K. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T19:03:20Z | |
| dc.date.available | 2015-11-24T19:03:20Z | |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19887 | |
| dc.rights | Default Licence | - |
| dc.subject | Humans | en |
| dc.subject | Ki-67 Antigen/*analysis | en |
| dc.subject | Neoplasm Staging | en |
| dc.subject | Proliferating Cell Nuclear Antigen/*analysis | en |
| dc.subject | Tumor Markers, Biological/*analysis | en |
| dc.subject | Tumor Suppressor Protein p53/*analysis | en |
| dc.subject | Urinary Bladder Neoplasms/*chemistry/pathology | en |
| dc.title | Tumor markers in stage P1 bladder cancer | en |
| heal.abstract | BACKGROUND: The infiltration of muscularis mucosa in superficial bladder cancer has been reported to be predictive of an unfavourable course of the disease. MATERIALS AND METHODS: We studied immunohistochemically Ki-67, PCNA and p53 tumour markers in 68 P1a and Pib bladder tumours. RESULTS: A statistically significant difference (p = 0.01) was found in the distribution of grades between stages P1a and P1b, with more grade 3 and less grade 2 tumours in the latter category. Univariate analysis revealed a strong association of Ki-67 (p = 0.001) and PCNA (p = 0.032) only with stage. P53 protein expression did not have any significant association with either stage or grade. In 60 patients entered into the multivariate analysis a clearly predominant, significant effect of stage on Ki-67 (p = 0.000) was shown. CONCLUSION: Increased proliferative activity when compared to P1a is present in P1b bladder tumours, as detected by the increased expression of Ki-67 proliferating antigen. The immunohistochemical study of Ki-67 antigen may help in predicting stage P1 tumours' behaviour, even in cases where pathological distinction of P1a and P1b substages is difficult. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11396238 | - |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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