Voxel-based morphometry and Voxel-based relaxometry in parkinsonian variant of multiple system atrophy
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tzarouchi, L. C.
Astrakas, L. G.
Konitsiotis, S.
Tsouli, S.
Margariti, P.
Zikou, A.
Argyropoulou, M. I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Neuroimaging
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA-P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel-based morphometry (VBM) and Voxel-based relaxometry (VBR) respectively, in MSA-P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA-P (aged 61.9 +/- 11.7 years, disease duration 5.42 +/- 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA-P. Normalization for atrophy should always be performed in T2 measurements.
Περιγραφή
Λέξεις-κλειδιά
Aged, Analysis of Variance, Brain/*pathology, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted/*methods, Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy/*pathology, Nerve Fibers, Myelinated/pathology, Nerve Fibers, Unmyelinated/pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19187475
http://onlinelibrary.wiley.com/store/10.1111/j.1552-6569.2008.00343.x/asset/j.1552-6569.2008.00343.x.pdf?v=1&t=h0krvk9j&s=5780720775588a64bfcd467c3631f38fadad77b4
http://onlinelibrary.wiley.com/store/10.1111/j.1552-6569.2008.00343.x/asset/j.1552-6569.2008.00343.x.pdf?v=1&t=h0krvk9j&s=5780720775588a64bfcd467c3631f38fadad77b4
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής