Voxel-based morphometry and Voxel-based relaxometry in parkinsonian variant of multiple system atrophy

Απλή σελίδα τεκμηρίου
dc.contributor.authorTzarouchi, L. C.en
dc.contributor.authorAstrakas, L. G.en
dc.contributor.authorKonitsiotis, S.en
dc.contributor.authorTsouli, S.en
dc.contributor.authorMargariti, P.en
dc.contributor.authorZikou, A.en
dc.contributor.authorArgyropoulou, M. I.en
dc.date.accessioned2015-11-24T19:34:13Z
dc.date.available2015-11-24T19:34:13Z
dc.identifier.issn1552-6569-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23609
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAnalysis of Varianceen
dc.subjectBrain/*pathologyen
dc.subjectBrain Mappingen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisted/*methodsen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMultiple System Atrophy/*pathologyen
dc.subjectNerve Fibers, Myelinated/pathologyen
dc.subjectNerve Fibers, Unmyelinated/pathologyen
dc.titleVoxel-based morphometry and Voxel-based relaxometry in parkinsonian variant of multiple system atrophyen
heal.abstractBACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA-P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel-based morphometry (VBM) and Voxel-based relaxometry (VBR) respectively, in MSA-P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA-P (aged 61.9 +/- 11.7 years, disease duration 5.42 +/- 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA-P. Normalization for atrophy should always be performed in T2 measurements.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1552-6569.2008.00343.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19187475-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1552-6569.2008.00343.x/asset/j.1552-6569.2008.00343.x.pdf?v=1&t=h0krvk9j&s=5780720775588a64bfcd467c3631f38fadad77b4-
heal.journalNameJ Neuroimagingen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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