Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Elisaf, M. S.
Tsatsoulis, A. A.
Katopodis, K. P.
Siamopoulos, K. C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Diabetes Res Clin Pract
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
We undertook the present study to examine the acid-base and electrolyte disturbances in relation to hydration status in patients with diabetic ketoacidosis (DKA). A total of 40 insulin-dependent diabetes mellitus patients (22 male, 18 female), aged 18-61 years with DKA admitted to our hospital during the last 2 years, were studied. The duration of diabetes averaged 9 +/- 2 years. In all cases a detailed investigation of the acid-base status and electrolyte parameters was performed. Twenty-one patients had a pure metabolic acidosis with an increased serum anion gap, seven had DKA combined with hyperchloremic metabolic acidosis, nine had DKA coexisting with metabolic alkalosis, while three had DKA with a concurrent respiratory alkalosis. Hydration status as evidenced by the ratio of urea/creatinine seems to play an important role in the development of mixed acid-base disorders (detected by changes in the ratios delta anion gap/delta bicarbonate (delta AG/delta HCO3) and sodium/chloride (Na/Cl)). In fact, hyperchloremic acidosis developed in the patients with the better hydration status. However, contradictorily, the severely dehydrated patients who experienced recurrent episodes of vomiting developed DKA with a concurrent metabolic alkalosis. Finally, patients with pneumonia or gram-negative septicemia exhibited DKA combined with a primary respiratory alkalosis. We conclude that patients with DKA commonly develop mixed acid-base disorders, which are partly dependent on patients' hydration status.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Analysis of Variance, Blood Glucose/analysis, Blood Proteins/analysis, Creatinine/blood, Diabetes Mellitus, Type 1/*blood, Diabetic Ketoacidosis/*blood, Electrolytes/*blood, Female, Humans, Male, Middle Aged, Regression Analysis, Urea/blood, Water-Electrolyte Imbalance/*blood/etiology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8968687
http://ac.els-cdn.com/S0168822796013320/1-s2.0-S0168822796013320-main.pdf?_tid=4934b5d617f8996ba071e76665df29c5&acdnat=1333693019_ce90b96056497de886eba4acf782d5c1
http://ac.els-cdn.com/S0168822796013320/1-s2.0-S0168822796013320-main.pdf?_tid=4934b5d617f8996ba071e76665df29c5&acdnat=1333693019_ce90b96056497de886eba4acf782d5c1
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής