Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Tsatsoulis, A. A. | en |
| dc.contributor.author | Katopodis, K. P. | en |
| dc.contributor.author | Siamopoulos, K. C. | en |
| dc.date.accessioned | 2015-11-24T19:38:20Z | |
| dc.date.available | 2015-11-24T19:38:20Z | |
| dc.identifier.issn | 0168-8227 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24137 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Analysis of Variance | en |
| dc.subject | Blood Glucose/analysis | en |
| dc.subject | Blood Proteins/analysis | en |
| dc.subject | Creatinine/blood | en |
| dc.subject | Diabetes Mellitus, Type 1/*blood | en |
| dc.subject | Diabetic Ketoacidosis/*blood | en |
| dc.subject | Electrolytes/*blood | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Regression Analysis | en |
| dc.subject | Urea/blood | en |
| dc.subject | Water-Electrolyte Imbalance/*blood/etiology | en |
| dc.title | Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis | en |
| heal.abstract | We undertook the present study to examine the acid-base and electrolyte disturbances in relation to hydration status in patients with diabetic ketoacidosis (DKA). A total of 40 insulin-dependent diabetes mellitus patients (22 male, 18 female), aged 18-61 years with DKA admitted to our hospital during the last 2 years, were studied. The duration of diabetes averaged 9 +/- 2 years. In all cases a detailed investigation of the acid-base status and electrolyte parameters was performed. Twenty-one patients had a pure metabolic acidosis with an increased serum anion gap, seven had DKA combined with hyperchloremic metabolic acidosis, nine had DKA coexisting with metabolic alkalosis, while three had DKA with a concurrent respiratory alkalosis. Hydration status as evidenced by the ratio of urea/creatinine seems to play an important role in the development of mixed acid-base disorders (detected by changes in the ratios delta anion gap/delta bicarbonate (delta AG/delta HCO3) and sodium/chloride (Na/Cl)). In fact, hyperchloremic acidosis developed in the patients with the better hydration status. However, contradictorily, the severely dehydrated patients who experienced recurrent episodes of vomiting developed DKA with a concurrent metabolic alkalosis. Finally, patients with pneumonia or gram-negative septicemia exhibited DKA combined with a primary respiratory alkalosis. We conclude that patients with DKA commonly develop mixed acid-base disorders, which are partly dependent on patients' hydration status. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8968687 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0168822796013320/1-s2.0-S0168822796013320-main.pdf?_tid=4934b5d617f8996ba071e76665df29c5&acdnat=1333693019_ce90b96056497de886eba4acf782d5c1 | - |
| heal.journalName | Diabetes Res Clin Pract | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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