Comparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo[a]pyrene-induced malignant tumors in rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Evangelou, A.
Karkabounas, S.
Kalpouzos, G.
Malamas, M.
Liasko, R.
Stefanou, D.
Vlahos, A. T.
Kabanos, T. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer Lett
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The antitumor effects of low dose administration of the vanadium(III) complexes with L-cysteine (complex 1) and N-(2-mercaptopropionyl)-glycine (complex 2) were compared on benzo[a]pyrene (BaP)-induced tumors in Wistar rats. Male Wistar rats, injected with 10.0 mg of BaP, were divided into one control (C-G) and two treatment (TR-G) groups of 17 animals each. Animals of the first treatment group were administered complex 2 (TR-2 group) and those of the second group were administered complex 1 (TR-1 group) at doses of 100 microg of vanadium per os daily, starting from the day a palpable tumor was developed till their death. BaP injection induced a 100% tumor (leiomyosarcomas) development in the animals of all groups. Administration of complex 1 to the animals resulted in a significant prolongation of the mean survival time, a complete remission of 17.6% of the tumors developed, a significant reduction of the carcinogenic potency (CP) of BaP and of the tumor growth rate (TGR) in TR-1 group animals, compared to the control and the TR-2 group. In marked contrast, complex 2 failed at the doses administered to exert any significant modulation of the above mentioned parameters. Results indicate that at low (100 micro/day) concentrations of vanadium, complex 1 exerts a significant anticarcinogenic effect on experimentally-induced leiomyosarcomas in rats, whereas complex 2 has no effect when administered at the same low concentrations of vanadium.
Περιγραφή
Λέξεις-κλειδιά
Animals, Antineoplastic Agents/*therapeutic use, Benzo(a)pyrene, Carcinogens, Drug Screening Assays, Antitumor, Leiomyosarcoma/chemically induced/*drug therapy, Male, Rats, Rats, Wistar, Sarcoma, Experimental/chemically induced/*drug therapy, Survival Analysis, Vanadium Compounds/*therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/9570375
http://ac.els-cdn.com/S0304383597002784/1-s2.0-S0304383597002784-main.pdf?_tid=102eef0df57a95761e38532fce1a5b65&acdnat=1332928200_b31c17c6fb753caced31b6bc9ec0efb2
http://ac.els-cdn.com/S0304383597002784/1-s2.0-S0304383597002784-main.pdf?_tid=102eef0df57a95761e38532fce1a5b65&acdnat=1332928200_b31c17c6fb753caced31b6bc9ec0efb2
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής