Comparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo[a]pyrene-induced malignant tumors in rats

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dc.contributor.authorEvangelou, A.en
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorKalpouzos, G.en
dc.contributor.authorMalamas, M.en
dc.contributor.authorLiasko, R.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorVlahos, A. T.en
dc.contributor.authorKabanos, T. A.en
dc.date.accessioned2015-11-24T19:28:17Z
dc.date.available2015-11-24T19:28:17Z
dc.identifier.issn0304-3835-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22886
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntineoplastic Agents/*therapeutic useen
dc.subjectBenzo(a)pyreneen
dc.subjectCarcinogensen
dc.subjectDrug Screening Assays, Antitumoren
dc.subjectLeiomyosarcoma/chemically induced/*drug therapyen
dc.subjectMaleen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectSarcoma, Experimental/chemically induced/*drug therapyen
dc.subjectSurvival Analysisen
dc.subjectVanadium Compounds/*therapeutic useen
dc.titleComparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo[a]pyrene-induced malignant tumors in ratsen
heal.abstractThe antitumor effects of low dose administration of the vanadium(III) complexes with L-cysteine (complex 1) and N-(2-mercaptopropionyl)-glycine (complex 2) were compared on benzo[a]pyrene (BaP)-induced tumors in Wistar rats. Male Wistar rats, injected with 10.0 mg of BaP, were divided into one control (C-G) and two treatment (TR-G) groups of 17 animals each. Animals of the first treatment group were administered complex 2 (TR-2 group) and those of the second group were administered complex 1 (TR-1 group) at doses of 100 microg of vanadium per os daily, starting from the day a palpable tumor was developed till their death. BaP injection induced a 100% tumor (leiomyosarcomas) development in the animals of all groups. Administration of complex 1 to the animals resulted in a significant prolongation of the mean survival time, a complete remission of 17.6% of the tumors developed, a significant reduction of the carcinogenic potency (CP) of BaP and of the tumor growth rate (TGR) in TR-1 group animals, compared to the control and the TR-2 group. In marked contrast, complex 2 failed at the doses administered to exert any significant modulation of the above mentioned parameters. Results indicate that at low (100 micro/day) concentrations of vanadium, complex 1 exerts a significant anticarcinogenic effect on experimentally-induced leiomyosarcomas in rats, whereas complex 2 has no effect when administered at the same low concentrations of vanadium.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9570375-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0304383597002784/1-s2.0-S0304383597002784-main.pdf?_tid=102eef0df57a95761e38532fce1a5b65&acdnat=1332928200_b31c17c6fb753caced31b6bc9ec0efb2-
heal.journalNameCancer Letten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1997-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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