Prognostic variable in patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy
Φόρτωση...
Ημερομηνία
Συγγραφείς
Fountzilas, G.
Gossios, K.
Zisiadis, A.
Svarna, E.
Skarlos, D.
Pavlidis, N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Med Pediatr Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Possible prognostic variables for tumor response, time to progression (TTP), and survival in 141 patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy were analyzed. None of the variables examined for their possible influence on tumor response attained significance in the stepwise logistic regression. In the univariate analysis, variables found to be strongly associated with TTP were performance status (PS) (P = 0.0301), liver involvement (P = 0.030), and the initial values of WBC (P = 0.0319), lactic dehydrogenase (LDH; P = 0.0053), gamma-glutamyl-transpeptidase (gamma-GT; P = 0.0013), alkaline phosphatase (ALP; P = 0.0186), albumin (P = 0.0004), and carcinoembryonic antigen (CEA; P = 0.0014). In the Cox analysis, liver involvement (P = 0.0553), albumin (P = 0.0181), PS (P = 0.484), and ALP (P = 0.0553) were retained as independently significant variables. When only patients with liver metastases were included in the analysis, then only albumin (P < 0.001) demonstrated a prognostic significance. Also, in the univariate analysis, variables predicting survival were PS (P = 0.0230), grade (P = 0.00600), liver involvement (P = 0.0002), LDH (P = 0.0001), gamma-GT (P < 0.001), ALP (P = 0.0006), albumin (P = 0.0309), and CEA (P = 0.005). With the multivariate analysis, gamma-GT (P = 0.0004), albumin (P = 0.0634), and CEA (P = 0.0804) were selected as significant. In those patients who presented with liver involvement, variables predicted survival were gamma-GT (P = 0.0041), albumin (P = 0.0442), and the percentage of involved liver parenchyma (P = 0.0690). These results could be helpful for the stratification of future trials in advanced colorectal cancer.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Analysis of Variance, Antimetabolites, Antineoplastic/*therapeutic use, Colorectal Neoplasms/*drug therapy/mortality/pathology, Female, Fluorouracil/*therapeutic use, Humans, Leucovorin/*therapeutic use, Male, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8614363
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-911X(199605)26:5<305::AID-MPO2>3.0.CO;2-M/asset/2_ftp.pdf?v=1&t=h0nhjy52&s=74add4f774254a4fec380b7f3d9654366a379264
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-911X(199605)26:5<305::AID-MPO2>3.0.CO;2-M/asset/2_ftp.pdf?v=1&t=h0nhjy52&s=74add4f774254a4fec380b7f3d9654366a379264
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής