Prognostic variable in patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy

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dc.contributor.authorFountzilas, G.en
dc.contributor.authorGossios, K.en
dc.contributor.authorZisiadis, A.en
dc.contributor.authorSvarna, E.en
dc.contributor.authorSkarlos, D.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T18:56:11Z
dc.date.available2015-11-24T18:56:11Z
dc.identifier.issn0098-1532-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18997
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnalysis of Varianceen
dc.subjectAntimetabolites, Antineoplastic/*therapeutic useen
dc.subjectColorectal Neoplasms/*drug therapy/mortality/pathologyen
dc.subjectFemaleen
dc.subjectFluorouracil/*therapeutic useen
dc.subjectHumansen
dc.subjectLeucovorin/*therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.titlePrognostic variable in patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapyen
heal.abstractPossible prognostic variables for tumor response, time to progression (TTP), and survival in 141 patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy were analyzed. None of the variables examined for their possible influence on tumor response attained significance in the stepwise logistic regression. In the univariate analysis, variables found to be strongly associated with TTP were performance status (PS) (P = 0.0301), liver involvement (P = 0.030), and the initial values of WBC (P = 0.0319), lactic dehydrogenase (LDH; P = 0.0053), gamma-glutamyl-transpeptidase (gamma-GT; P = 0.0013), alkaline phosphatase (ALP; P = 0.0186), albumin (P = 0.0004), and carcinoembryonic antigen (CEA; P = 0.0014). In the Cox analysis, liver involvement (P = 0.0553), albumin (P = 0.0181), PS (P = 0.484), and ALP (P = 0.0553) were retained as independently significant variables. When only patients with liver metastases were included in the analysis, then only albumin (P < 0.001) demonstrated a prognostic significance. Also, in the univariate analysis, variables predicting survival were PS (P = 0.0230), grade (P = 0.00600), liver involvement (P = 0.0002), LDH (P = 0.0001), gamma-GT (P < 0.001), ALP (P = 0.0006), albumin (P = 0.0309), and CEA (P = 0.005). With the multivariate analysis, gamma-GT (P = 0.0004), albumin (P = 0.0634), and CEA (P = 0.0804) were selected as significant. In those patients who presented with liver involvement, variables predicted survival were gamma-GT (P = 0.0041), albumin (P = 0.0442), and the percentage of involved liver parenchyma (P = 0.0690). These results could be helpful for the stratification of future trials in advanced colorectal cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/(SICI)1096-911X(199605)26:5<305::AID-MPO2>3.0.CO;2-M-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8614363-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-911X(199605)26:5<305::AID-MPO2>3.0.CO;2-M/asset/2_ftp.pdf?v=1&t=h0nhjy52&s=74add4f774254a4fec380b7f3d9654366a379264-
heal.journalNameMed Pediatr Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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