Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia
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Sipsas, N. V.
Kokori, S. I.
Ioannidis, J. P.
Kyriaki, D.
Tzioufas, A. G.
Kordossis, T.
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peer-reviewed
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J Infect Dis
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In a cohort of 204 unselected consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients, the association of circulating autoantibodies to endogenous erythropoietin (EPO) with HIV-1-related anemia was studied. Circulating autoantibodies to EPO were present in 48 (23.5%) of the 204 patients studied. Circulating autoantibodies were an independent predictor of anemia (odds ratio [OR]=5.0; 95% confidence interval [CI], 2.5-9.9), as strong as other known causes of anemia. The association of anti-EPO antibodies with anemia became stronger when the analysis was limited to the group of patients without any medical condition causing anemia (OR=10.4; 95% CI, 3.2-33.9). Moreover, the effect on hemoglobin levels remained significant even after adjusting for other anemia parameters. Anti-EPO autoantibodies were associated with higher EPO levels (r=.25, P=.012) and with a more prominent EPO response to anemia. Our findings suggest that autoimmunity, among other factors, may contribute to the pathogenesis of HIV-1-related anemia.
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Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Anemia/*etiology, Autoantibodies/*blood, Cohort Studies, Erythropoietin/analysis/*immunology, Female, HIV Infections/*complications/immunology, *Hiv-1, Hemoglobins/analysis, Humans, Male, Middle Aged
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http://www.ncbi.nlm.nih.gov/pubmed/10558967
http://jid.oxfordjournals.org/content/180/6/2044.full.pdf
http://jid.oxfordjournals.org/content/180/6/2044.full.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής