Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia
| dc.contributor.author | Sipsas, N. V. | en |
| dc.contributor.author | Kokori, S. I. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Kyriaki, D. | en |
| dc.contributor.author | Tzioufas, A. G. | en |
| dc.contributor.author | Kordossis, T. | en |
| dc.date.accessioned | 2015-11-24T19:30:31Z | |
| dc.date.available | 2015-11-24T19:30:31Z | |
| dc.identifier.issn | 0022-1899 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23113 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Anemia/*etiology | en |
| dc.subject | Autoantibodies/*blood | en |
| dc.subject | Cohort Studies | en |
| dc.subject | Erythropoietin/analysis/*immunology | en |
| dc.subject | Female | en |
| dc.subject | HIV Infections/*complications/immunology | en |
| dc.subject | *Hiv-1 | en |
| dc.subject | Hemoglobins/analysis | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.title | Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia | en |
| heal.abstract | In a cohort of 204 unselected consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients, the association of circulating autoantibodies to endogenous erythropoietin (EPO) with HIV-1-related anemia was studied. Circulating autoantibodies to EPO were present in 48 (23.5%) of the 204 patients studied. Circulating autoantibodies were an independent predictor of anemia (odds ratio [OR]=5.0; 95% confidence interval [CI], 2.5-9.9), as strong as other known causes of anemia. The association of anti-EPO antibodies with anemia became stronger when the analysis was limited to the group of patients without any medical condition causing anemia (OR=10.4; 95% CI, 3.2-33.9). Moreover, the effect on hemoglobin levels remained significant even after adjusting for other anemia parameters. Anti-EPO autoantibodies were associated with higher EPO levels (r=.25, P=.012) and with a more prominent EPO response to anemia. Our findings suggest that autoimmunity, among other factors, may contribute to the pathogenesis of HIV-1-related anemia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1086/315156 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10558967 | - |
| heal.identifier.secondary | http://jid.oxfordjournals.org/content/180/6/2044.full.pdf | - |
| heal.journalName | J Infect Dis | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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