Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer
Φόρτωση...
Ημερομηνία
Συγγραφείς
Vairaktaris, E.
Yapijakis, C.
Tsigris, C.
Vassiliou, S.
Derka, S.
Nkenke, E.
Spyridonidou, S.
Vylliotis, A.
Vorris, E.
Ragos, V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Acta Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
INTRODUCTION: In light to recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of angiotensin I- converting enzyme (ACE) with increased risk for oral cancer. MATERIALS AND METHODS: In DNA samples of 160 patients with oral squamous cell carcinoma and 153 healthy controls of comparable ethnicity, age and sex, we studied the insertion/deletion (I/D) polymorphism in the ACE gene, which affects its transcription. RESULTS: The I allele frequencies were significantly increased in patients compared to controls, 40.6% versus 27.5% (p < 0.001), respectively. The II homozygotes had a three-fold greater risk for developing oral cancer (odds ratio 3.17, 95% C.I. 1.32-7.61). A significant increase of I alleles was observed in patients regardless their smoking or alcohol consumption habits, early or advanced stage of cancer, presence or absence of a family history for cancer or thrombophilia (Fischer values p < 0.05). DISCUSSION: These findings suggest that the I/D polymorphism, by affecting the ACE gene expression, is associated with the progress of oral oncogenesis.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/*genetics, Case-Control Studies, Disease Progression, Female, Gene Frequency, *Genetic Predisposition to Disease, Genotype, Germany, Greece, Humans, *INDEL Mutation, Male, Middle Aged, Mouth Neoplasms/*genetics, Peptidyl-Dipeptidase A/*genetics, *Polymorphism, Genetic, Risk
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17851834
http://informahealthcare.com/doi/pdfplus/10.1080/02841860701373579
http://informahealthcare.com/doi/pdfplus/10.1080/02841860701373579
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής