Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer

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dc.contributor.authorVairaktaris, E.en
dc.contributor.authorYapijakis, C.en
dc.contributor.authorTsigris, C.en
dc.contributor.authorVassiliou, S.en
dc.contributor.authorDerka, S.en
dc.contributor.authorNkenke, E.en
dc.contributor.authorSpyridonidou, S.en
dc.contributor.authorVylliotis, A.en
dc.contributor.authorVorris, E.en
dc.contributor.authorRagos, V.en
dc.contributor.authorNeukam, F. W.en
dc.contributor.authorPatsouris, E.en
dc.date.accessioned2015-11-24T19:34:58Z
dc.date.available2015-11-24T19:34:58Z
dc.identifier.issn0284-186X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23667
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCarcinoma, Squamous Cell/*geneticsen
dc.subjectCase-Control Studiesen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectGermanyen
dc.subjectGreeceen
dc.subjectHumansen
dc.subject*INDEL Mutationen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMouth Neoplasms/*geneticsen
dc.subjectPeptidyl-Dipeptidase A/*geneticsen
dc.subject*Polymorphism, Geneticen
dc.subjectRisken
dc.titleAssociation of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral canceren
heal.abstractINTRODUCTION: In light to recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of angiotensin I- converting enzyme (ACE) with increased risk for oral cancer. MATERIALS AND METHODS: In DNA samples of 160 patients with oral squamous cell carcinoma and 153 healthy controls of comparable ethnicity, age and sex, we studied the insertion/deletion (I/D) polymorphism in the ACE gene, which affects its transcription. RESULTS: The I allele frequencies were significantly increased in patients compared to controls, 40.6% versus 27.5% (p < 0.001), respectively. The II homozygotes had a three-fold greater risk for developing oral cancer (odds ratio 3.17, 95% C.I. 1.32-7.61). A significant increase of I alleles was observed in patients regardless their smoking or alcohol consumption habits, early or advanced stage of cancer, presence or absence of a family history for cancer or thrombophilia (Fischer values p < 0.05). DISCUSSION: These findings suggest that the I/D polymorphism, by affecting the ACE gene expression, is associated with the progress of oral oncogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1080/02841860701373579-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17851834-
heal.identifier.secondaryhttp://informahealthcare.com/doi/pdfplus/10.1080/02841860701373579-
heal.journalNameActa Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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