A comparative study of the behavioral effects of d-amphetamine and apomorphine in the rat
Φόρτωση...
Ημερομηνία
Συγγραφείς
Antoniou, K.
Kafetzopoulos, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pharmacol Biochem Behav
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
A wide range of doses of d-amphetamine and apomorphine were injected into rats, in order to better characterize and compare dopaminergic agonist-induced behavioral effects. The study was carried out using a computerized technique for the quantification and analysis of various behavioral elements. Although both drugs increased motor activity and provided dose-dependent stereotyped responses, the whole pattern of behavior in the open field showed a different structure. d-Amphetamine in doses that did not produce stereotyped responses induced a wide range of varied behavioral elements with increased frequency but decreased mean duration, while apomorphine induced a more restricted behavioral profile. Furthermore, a higher frequency of freezing reaction was observed after d-amphetamine treatment in low doses but not after apomorphine treatment. Both drugs in high doses elicited a similar stereotyped syndrome characterized by repetitive movements of great duration, but at low doses the behavioral pattern was completely different. The apomorphine-induced syndrome was characterized mainly by moving and sniffing, interrupted by rearing, while the amphetamine-induced syndrome by sniffing and moving, interrupted by standing and freezing.
Περιγραφή
Λέξεις-κλειδιά
Animals, Apomorphine/*pharmacology, Behavior, Animal/*drug effects, Dextroamphetamine/*pharmacology, Grooming/drug effects, Male, Motor Activity/drug effects, Rats, Rats, Inbred Strains, Stereotyped Behavior/drug effects, Yawning/drug effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/1924514
http://ac.els-cdn.com/009130579190398L/1-s2.0-009130579190398L-main.pdf?_tid=55d45910a980627c0b2b0a1e9865a7e1&acdnat=1332923767_bd5e3786d619eb73d44c580f328147b4
http://ac.els-cdn.com/009130579190398L/1-s2.0-009130579190398L-main.pdf?_tid=55d45910a980627c0b2b0a1e9865a7e1&acdnat=1332923767_bd5e3786d619eb73d44c580f328147b4
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής