A comparative study of the behavioral effects of d-amphetamine and apomorphine in the rat
| dc.contributor.author | Antoniou, K. | en |
| dc.contributor.author | Kafetzopoulos, E. | en |
| dc.date.accessioned | 2015-11-24T19:40:34Z | |
| dc.date.available | 2015-11-24T19:40:34Z | |
| dc.identifier.issn | 0091-3057 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24372 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Apomorphine/*pharmacology | en |
| dc.subject | Behavior, Animal/*drug effects | en |
| dc.subject | Dextroamphetamine/*pharmacology | en |
| dc.subject | Grooming/drug effects | en |
| dc.subject | Male | en |
| dc.subject | Motor Activity/drug effects | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Stereotyped Behavior/drug effects | en |
| dc.subject | Yawning/drug effects | en |
| dc.title | A comparative study of the behavioral effects of d-amphetamine and apomorphine in the rat | en |
| heal.abstract | A wide range of doses of d-amphetamine and apomorphine were injected into rats, in order to better characterize and compare dopaminergic agonist-induced behavioral effects. The study was carried out using a computerized technique for the quantification and analysis of various behavioral elements. Although both drugs increased motor activity and provided dose-dependent stereotyped responses, the whole pattern of behavior in the open field showed a different structure. d-Amphetamine in doses that did not produce stereotyped responses induced a wide range of varied behavioral elements with increased frequency but decreased mean duration, while apomorphine induced a more restricted behavioral profile. Furthermore, a higher frequency of freezing reaction was observed after d-amphetamine treatment in low doses but not after apomorphine treatment. Both drugs in high doses elicited a similar stereotyped syndrome characterized by repetitive movements of great duration, but at low doses the behavioral pattern was completely different. The apomorphine-induced syndrome was characterized mainly by moving and sniffing, interrupted by rearing, while the amphetamine-induced syndrome by sniffing and moving, interrupted by standing and freezing. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1924514 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/009130579190398L/1-s2.0-009130579190398L-main.pdf?_tid=55d45910a980627c0b2b0a1e9865a7e1&acdnat=1332923767_bd5e3786d619eb73d44c580f328147b4 | - |
| heal.journalName | Pharmacol Biochem Behav | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1991 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: