Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population
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Miltiadous, G.
Hatzivassiliou, M.
Liberopoulos, E.
Bairaktari, E.
Tselepis, A.
Cariolou, M.
Elisaf, M.
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peer reviewed
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Nutrition Metabolism and Cardiovascular Diseases
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Background and Aim: HDL-cholesterot (HDL-C) is inversely related to the risk of ischemic heart disease. Many genes are reported to affect HDL-C serum levels in both hyperlipidemic and normolipidemic populations, though the data are controversial. We examined the effect of common gene polymorphisms known to interfere with HDL-C metabolism (apolipoprotein E, cholesterol ester transfer protein and apolipoprotein A-IV gene polymorphisms) on HDL-C plasma levels in normolipidemic subjects. Methods and results: The study population consisted of 200 normolipidernic individuals visiting our clinic for a routine check-up. None of the above gene polymorphisms affected HDL-C levels in our population. However, participants carrying the atlete E4 of the apolipoprotein (apo) E gene, the allele B1 of the TaqIB polymorphisms in the cholesterol ester transfer protein (CETP) gene and the allele T of the apoA-IV gene (A to T polymorphism at site 347) (n=28) had statistically significantly tower HDL-C levels compared to those not carrying the above allele combination (0.99+0.33 vs 1.28 0.35 mmol/L, p=0.04). Conclusion: In this study, we describe a subgroup of normolipidemic individuals with low HDL-C levels due to genetic variability, and we discuss the underlying possible mechanisms involved. (c) 2005 Elsevier Ltd. All. rights reserved.
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hdl-cholesterol, genes, apolipoprotein e, apolipoprotein a iv, cholesterol ester transfer protein, apolipoprotein-a-iv, high-density-lipoproteins, transfer protein-activity, frequency, heterogeneity, sites, locus, cetp
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<Go to ISI>://000230318700010
http://ac.els-cdn.com/S0939475305000451/1-s2.0-S0939475305000451-main.pdf?_tid=40233cf43599e4275ef2af4ab6b5cf42&acdnat=1333111627_b1831f90cee312120e31ab2f6fb5e283
http://ac.els-cdn.com/S0939475305000451/1-s2.0-S0939475305000451-main.pdf?_tid=40233cf43599e4275ef2af4ab6b5cf42&acdnat=1333111627_b1831f90cee312120e31ab2f6fb5e283
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας