Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population
| dc.contributor.author | Miltiadous, G. | en |
| dc.contributor.author | Hatzivassiliou, M. | en |
| dc.contributor.author | Liberopoulos, E. | en |
| dc.contributor.author | Bairaktari, E. | en |
| dc.contributor.author | Tselepis, A. | en |
| dc.contributor.author | Cariolou, M. | en |
| dc.contributor.author | Elisaf, M. | en |
| dc.date.accessioned | 2015-11-24T16:38:27Z | |
| dc.date.available | 2015-11-24T16:38:27Z | |
| dc.identifier.issn | 0939-4753 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8047 | |
| dc.rights | Default Licence | - |
| dc.subject | hdl-cholesterol | en |
| dc.subject | genes | en |
| dc.subject | apolipoprotein e | en |
| dc.subject | apolipoprotein a iv | en |
| dc.subject | cholesterol ester transfer protein | en |
| dc.subject | apolipoprotein-a-iv | en |
| dc.subject | high-density-lipoproteins | en |
| dc.subject | transfer protein-activity | en |
| dc.subject | frequency | en |
| dc.subject | heterogeneity | en |
| dc.subject | sites | en |
| dc.subject | locus | en |
| dc.subject | cetp | en |
| dc.title | Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population | en |
| heal.abstract | Background and Aim: HDL-cholesterot (HDL-C) is inversely related to the risk of ischemic heart disease. Many genes are reported to affect HDL-C serum levels in both hyperlipidemic and normolipidemic populations, though the data are controversial. We examined the effect of common gene polymorphisms known to interfere with HDL-C metabolism (apolipoprotein E, cholesterol ester transfer protein and apolipoprotein A-IV gene polymorphisms) on HDL-C plasma levels in normolipidemic subjects. Methods and results: The study population consisted of 200 normolipidernic individuals visiting our clinic for a routine check-up. None of the above gene polymorphisms affected HDL-C levels in our population. However, participants carrying the atlete E4 of the apolipoprotein (apo) E gene, the allele B1 of the TaqIB polymorphisms in the cholesterol ester transfer protein (CETP) gene and the allele T of the apoA-IV gene (A to T polymorphism at site 347) (n=28) had statistically significantly tower HDL-C levels compared to those not carrying the above allele combination (0.99+0.33 vs 1.28 0.35 mmol/L, p=0.04). Conclusion: In this study, we describe a subgroup of normolipidemic individuals with low HDL-C levels due to genetic variability, and we discuss the underlying possible mechanisms involved. (c) 2005 Elsevier Ltd. All. rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1016/j.numced.2004.09.004 | - |
| heal.identifier.secondary | <Go to ISI>://000230318700010 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0939475305000451/1-s2.0-S0939475305000451-main.pdf?_tid=40233cf43599e4275ef2af4ab6b5cf42&acdnat=1333111627_b1831f90cee312120e31ab2f6fb5e283 | - |
| heal.journalName | Nutrition Metabolism and Cardiovascular Diseases | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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