Plasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with beta-thalassemia
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tselepis, A. D.
Hahalis, G.
Tellis, C. C.
Papavasiliou, E. C.
Mylona, P. T.
Kourakli, A.
Alexopoulos, D. C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
American Society for Biochemistry and Molecular Biology, Inc.
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Lipid Research
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA(2) activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with beta-thalassemia. Thirty-five patients with beta-thalassemia major (beta-TM) and 25 patients with beta-thalassemia intermedia (beta-TI) participated in the study. Lp-PLA(2) activity and mass were measured in total plasma, in apolipoprotein (apo) B-depleted plasma (HDL-Lp- PLA(2)), and in LDL subclasses. Lp-PLA(2) activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with beta-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA(2) mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA(2) activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA(2) activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA(2) activity and mass as well as the ratio of HDL-Lp-PLA(2)/plasma Lp-PLA(2) were significantly higher in both patient groups compared with the control group. In conclusion, patients with beta-thalassemia exhibit high plasma Lp-PLA(2) levels, attributed to increased enzyme secretion from monocytes/macrophages and to the predominance of sdLDL particles in plasma. Plasma Lp-PLA(2) is correlated with carotid IMT, suggesting that this enzyme may be implicated in premature carotid atherosclerosis observed in beta-thalassemia.-Tselepis, A. D., G. Hahalis, C. C. Tellis, E. C. Papavasiliou, P. T. Mylona, A. Kourakli, and D. C. Alexopoulos. Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with beta-thalassemia. J. Lipid Res. 2010. 51: 3331-3341.
Περιγραφή
Λέξεις-κλειδιά
low density lipoprotein, high density lipoprotein, oxidative stress, atherosclerosis, platelet-activating-factor, low-density-lipoprotein, factor-acetylhydrolase activity, sickle-cell-disease, paf-acetylhydrolase, oxidative stress, coronary atherosclerosis, endothelial dysfunction, ldl, expression
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000282808200026
http://www.jlr.org/content/51/11/3331.full.pdf
http://www.jlr.org/content/51/11/3331.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας