Plasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with beta-thalassemia

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dc.contributor.authorTselepis, A. D.en
dc.contributor.authorHahalis, G.en
dc.contributor.authorTellis, C. C.en
dc.contributor.authorPapavasiliou, E. C.en
dc.contributor.authorMylona, P. T.en
dc.contributor.authorKourakli, A.en
dc.contributor.authorAlexopoulos, D. C.en
dc.date.accessioned2015-11-24T16:44:57Z
dc.date.available2015-11-24T16:44:57Z
dc.identifier.issn0022-2275-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8856
dc.rightsDefault Licence-
dc.subjectlow density lipoproteinen
dc.subjecthigh density lipoproteinen
dc.subjectoxidative stressen
dc.subjectatherosclerosisen
dc.subjectplatelet-activating-factoren
dc.subjectlow-density-lipoproteinen
dc.subjectfactor-acetylhydrolase activityen
dc.subjectsickle-cell-diseaseen
dc.subjectpaf-acetylhydrolaseen
dc.subjectoxidative stressen
dc.subjectcoronary atherosclerosisen
dc.subjectendothelial dysfunctionen
dc.subjectldlen
dc.subjectexpressionen
dc.titlePlasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with beta-thalassemiaen
heal.abstractLipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA(2) activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with beta-thalassemia. Thirty-five patients with beta-thalassemia major (beta-TM) and 25 patients with beta-thalassemia intermedia (beta-TI) participated in the study. Lp-PLA(2) activity and mass were measured in total plasma, in apolipoprotein (apo) B-depleted plasma (HDL-Lp- PLA(2)), and in LDL subclasses. Lp-PLA(2) activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with beta-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA(2) mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA(2) activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA(2) activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA(2) activity and mass as well as the ratio of HDL-Lp-PLA(2)/plasma Lp-PLA(2) were significantly higher in both patient groups compared with the control group. In conclusion, patients with beta-thalassemia exhibit high plasma Lp-PLA(2) levels, attributed to increased enzyme secretion from monocytes/macrophages and to the predominance of sdLDL particles in plasma. Plasma Lp-PLA(2) is correlated with carotid IMT, suggesting that this enzyme may be implicated in premature carotid atherosclerosis observed in beta-thalassemia.-Tselepis, A. D., G. Hahalis, C. C. Tellis, E. C. Papavasiliou, P. T. Mylona, A. Kourakli, and D. C. Alexopoulos. Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with beta-thalassemia. J. Lipid Res. 2010. 51: 3331-3341.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1194/Jlr.M007229-
heal.identifier.secondary<Go to ISI>://000282808200026-
heal.identifier.secondaryhttp://www.jlr.org/content/51/11/3331.full.pdf-
heal.journalNameJournal of Lipid Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2010-
heal.publisherAmerican Society for Biochemistry and Molecular Biology, Inc.en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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