Structural Aspects of Thiamine, Its Derivatives and Their Metal-Complexes in Relation to the Enzymatic Action of Thiamine Enzymes
Loading...
Date
Authors
Louloudi, M.
Hadjiliadis, N.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Type
Type of the conference item
Journal type
peer reviewed
Educational material type
Conference Name
Journal name
Coordination Chemistry Reviews
Book name
Book series
Book edition
Alternative title / Subtitle
Description
A review is given of the mechanism of the enzymatic action of thiamine (vitamin B-1) enzymes, based mainly on the metal complexes and the crystal structures of the ligand and its derivatives. It consists of three parts. Part 1 is a general introduction. Part 2 emphasizes the role of the pyrimidine and thiazole moities of thiamine and also of the pyrophosphate group and the bivalent metal ions in the enzymatic action, covered in four subsections referred to each of the above labels, the last of which describes the crystal structures of thiamine, its derivatives and their metal complexes. It attempts a correlation of the crystallographic data with the proposed mechanisms of the enzymatic action of thiamine. Part 3 is the conclusion, pointing to the stage of intervention of the metal ions and expanding the importance of the S conformation of the ligand during the enzymatic action of thiamine enzymes.
Description
Keywords
nuclear-magnetic-resonance, chloride hydrochloride trihydrate, crystal-structure, molecular-structure, ion interactions, coenzyme interactions, aldehyde derivatives, divalent-cations, monohydrate, pyrophosphate
Subject classification
Citation
Link
<Go to ISI>://A1994PU57200012
http://ac.els-cdn.com/001085459480074X/1-s2.0-001085459480074X-main.pdf?_tid=90759e4e-362e-11e3-923b-00000aacb35e&acdnat=1381906117_dd2d15578e29ebbd190246072547aa61
http://ac.els-cdn.com/001085459480074X/1-s2.0-001085459480074X-main.pdf?_tid=90759e4e-362e-11e3-923b-00000aacb35e&acdnat=1381906117_dd2d15578e29ebbd190246072547aa61
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας