Structural Aspects of Thiamine, Its Derivatives and Their Metal-Complexes in Relation to the Enzymatic Action of Thiamine Enzymes

dc.contributor.authorLouloudi, M.en
dc.contributor.authorHadjiliadis, N.en
dc.date.accessioned2015-11-24T16:48:00Z
dc.date.available2015-11-24T16:48:00Z
dc.identifier.issn0010-8545-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9268
dc.rightsDefault Licence-
dc.subjectnuclear-magnetic-resonanceen
dc.subjectchloride hydrochloride trihydrateen
dc.subjectcrystal-structureen
dc.subjectmolecular-structureen
dc.subjection interactionsen
dc.subjectcoenzyme interactionsen
dc.subjectaldehyde derivativesen
dc.subjectdivalent-cationsen
dc.subjectmonohydrateen
dc.subjectpyrophosphateen
dc.titleStructural Aspects of Thiamine, Its Derivatives and Their Metal-Complexes in Relation to the Enzymatic Action of Thiamine Enzymesen
heal.abstractA review is given of the mechanism of the enzymatic action of thiamine (vitamin B-1) enzymes, based mainly on the metal complexes and the crystal structures of the ligand and its derivatives. It consists of three parts. Part 1 is a general introduction. Part 2 emphasizes the role of the pyrimidine and thiazole moities of thiamine and also of the pyrophosphate group and the bivalent metal ions in the enzymatic action, covered in four subsections referred to each of the above labels, the last of which describes the crystal structures of thiamine, its derivatives and their metal complexes. It attempts a correlation of the crystallographic data with the proposed mechanisms of the enzymatic action of thiamine. Part 3 is the conclusion, pointing to the stage of intervention of the metal ions and expanding the importance of the S conformation of the ligand during the enzymatic action of thiamine enzymes.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1016/0010-8545(94)80074-X-
heal.identifier.secondary<Go to ISI>://A1994PU57200012-
heal.identifier.secondaryhttp://ac.els-cdn.com/001085459480074X/1-s2.0-001085459480074X-main.pdf?_tid=90759e4e-362e-11e3-923b-00000aacb35e&acdnat=1381906117_dd2d15578e29ebbd190246072547aa61-
heal.journalNameCoordination Chemistry Reviewsen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1994-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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