Solution phase synthesis of a spiro[pyrrolidine-2,3 '-oxindole] library via a three component 1,3-dipolar cycloaddition reaction

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dc.contributor.authorFokas, D.en
dc.contributor.authorRyan, W. J.en
dc.contributor.authorCasebier, D. S.en
dc.contributor.authorCoffen, D. L.en
dc.date.accessioned2015-11-24T17:38:27Z
dc.date.available2015-11-24T17:38:27Z
dc.identifier.issn0040-4039-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/14494
dc.rightsDefault Licence-
dc.subjectdecarboxylative transaminationen
dc.subjectazomethine ylidesen
dc.subjectrouteen
dc.subjectmechanismen
dc.titleSolution phase synthesis of a spiro[pyrrolidine-2,3 '-oxindole] library via a three component 1,3-dipolar cycloaddition reactionen
heal.abstractA combinatorial library of 26,500 spiro[pyrrolidine-2,3'-oxindoles] was prepared in a single-compound format by a facile intermolecular 1,3-dipolar cycloaddition. An azomethine ylide, generated by the decarboxylative condensation of an isatin 1 with an alpha-amino acid 2, was trapped by a trans-chalcone 3 to afford heterocycles of the general structure 4. The regio-and stereochemistry of a representative product was determined by single crystal X-ray structure. (C) 1998 Elsevier Science Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1016/S0040-4039(98)00234-2-
heal.identifier.secondary<Go to ISI>://000072824900004-
heal.journalNameTetrahedron Letten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1998-
heal.publisherPergamon - Elsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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