Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial
Φόρτωση...
Ημερομηνία
Συγγραφείς
Dimitriadis, F.
Tsambalas, S.
Tsounapi, P.
Kawamura, H.
Vlachopoulou, E.
Haliasos, N.
Gratsias, S.
Watanabe, T.
Saito, M.
Miyagawa, I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Bju International
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: to evaluate the effects of phosphodiesterase-5 inhibitors (PDE5-i) on Leydig cell secretory function (LCSF). PATIENTS AND METHODS: in all, 75 men with oligoasthenospermia were treated daily for 12 weeks with either vardenafil (23 men, group A), sildenafil (25 men, group B) or l-carnitine (26 men, group C); a further group of 22 men with oligoasthenospermia (group D) received no treatment. Serum levels of insulin-like-3 peptide (INSL3) were evaluated before and after the end of the treatment in each of groups A, B and C, respectively. Serum INSL3 levels were measured in each participant of group D before and after the 12-week experimental period. RESULTS: within group A and B, the peripheral serum mean INSL3 concentration, sperm concentration, percentage of motile spermatozoa, and percentage of morphologically normal spermatozoa were significantly greater after PDE5-i treatment than before. CONCLUSION: we suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.
Περιγραφή
Λέξεις-κλειδιά
Analysis of Variance, Carnitine, Humans, Imidazoles, Insulin/blood/*secretion, Leydig Cells/*drug effects/secretion, Male, Oligospermia/blood/*drug therapy, Phosphodiesterase 5 Inhibitors/*therapeutic use, Piperazines, Proteins/*secretion, Purines, Sperm Count, Sperm Motility, Sulfones, Treatment Outcome, Triazines
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/20184572
http://onlinelibrary.wiley.com/store/10.1111/j.1464-410X.2010.09243.x/asset/j.1464-410X.2010.09243.x.pdf?v=1&t=h0p89syp&s=65ca4e7d950fd44db8b7363c1b098e22a293b18a
http://onlinelibrary.wiley.com/store/10.1111/j.1464-410X.2010.09243.x/asset/j.1464-410X.2010.09243.x.pdf?v=1&t=h0p89syp&s=65ca4e7d950fd44db8b7363c1b098e22a293b18a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής