Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial

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dc.contributor.authorDimitriadis, F.en
dc.contributor.authorTsambalas, S.en
dc.contributor.authorTsounapi, P.en
dc.contributor.authorKawamura, H.en
dc.contributor.authorVlachopoulou, E.en
dc.contributor.authorHaliasos, N.en
dc.contributor.authorGratsias, S.en
dc.contributor.authorWatanabe, T.en
dc.contributor.authorSaito, M.en
dc.contributor.authorMiyagawa, I.en
dc.contributor.authorSofikitis, N.en
dc.date.accessioned2015-11-24T19:20:52Z
dc.date.available2015-11-24T19:20:52Z
dc.identifier.issn1464-410X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22069
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectCarnitineen
dc.subjectHumansen
dc.subjectImidazolesen
dc.subjectInsulin/blood/*secretionen
dc.subjectLeydig Cells/*drug effects/secretionen
dc.subjectMaleen
dc.subjectOligospermia/blood/*drug therapyen
dc.subjectPhosphodiesterase 5 Inhibitors/*therapeutic useen
dc.subjectPiperazinesen
dc.subjectProteins/*secretionen
dc.subjectPurinesen
dc.subjectSperm Counten
dc.subjectSperm Motilityen
dc.subjectSulfonesen
dc.subjectTreatment Outcomeen
dc.subjectTriazinesen
dc.titleEffects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trialen
heal.abstractOBJECTIVE: to evaluate the effects of phosphodiesterase-5 inhibitors (PDE5-i) on Leydig cell secretory function (LCSF). PATIENTS AND METHODS: in all, 75 men with oligoasthenospermia were treated daily for 12 weeks with either vardenafil (23 men, group A), sildenafil (25 men, group B) or l-carnitine (26 men, group C); a further group of 22 men with oligoasthenospermia (group D) received no treatment. Serum levels of insulin-like-3 peptide (INSL3) were evaluated before and after the end of the treatment in each of groups A, B and C, respectively. Serum INSL3 levels were measured in each participant of group D before and after the 12-week experimental period. RESULTS: within group A and B, the peripheral serum mean INSL3 concentration, sperm concentration, percentage of motile spermatozoa, and percentage of morphologically normal spermatozoa were significantly greater after PDE5-i treatment than before. CONCLUSION: we suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1464-410X.2010.09243.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20184572-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1464-410X.2010.09243.x/asset/j.1464-410X.2010.09243.x.pdf?v=1&t=h0p89syp&s=65ca4e7d950fd44db8b7363c1b098e22a293b18a-
heal.journalNameBju Internationalen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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