Solvation State of the Tyr Side-Chain in Peptides - an Ft-Ir and O-17 Nmr Approach
| dc.contributor.author | Gerothanassis, I. P. | en |
| dc.contributor.author | Birlirakis, N. | en |
| dc.contributor.author | Sakarellos, C. | en |
| dc.contributor.author | Marraud, M. | en |
| dc.date.accessioned | 2015-11-24T16:47:35Z | |
| dc.date.available | 2015-11-24T16:47:35Z | |
| dc.identifier.issn | 0002-7863 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9207 | |
| dc.rights | Default Licence | - |
| dc.subject | protein amino-acids | en |
| dc.subject | aqueous-solution | en |
| dc.subject | organic solution | en |
| dc.subject | enkephalin | en |
| dc.subject | tyrosine | en |
| dc.subject | bacteriorhodopsin | en |
| dc.subject | spectroscopy | en |
| dc.subject | polypeptides | en |
| dc.subject | morphine | en |
| dc.subject | spectra | en |
| dc.title | Solvation State of the Tyr Side-Chain in Peptides - an Ft-Ir and O-17 Nmr Approach | en |
| heal.abstract | Detailed studies of the O-17 NMR chemical shifts of the COH group of p-cresol and tyrosine derivatives as a function of pH and in a variety of solvents revealed an unusually large titration shift upon the deprotonation of the phenol group and a very small chemical shift variation as a function of solvent hydrogen-bonding ability. Similarly the nu(CO) stretching frequencies exhibit a very small variation as a function of solvent hydrogen-bonding ability, and discrete hydrogen-bonded species could not be identified. In contrast, the in-plane COH bending frequencies of these compounds have been shown to be very sensitive to hydrogen-bond interactions, and discrete hydrogen-bonded species could be identified. The applicability of this novel methodology to peptide hormones is demonstrated in the case of Leu-enkephalin in aqueous solution. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://A1992JW79700041 | - |
| heal.identifier.secondary | http://pubs.acs.org/doi/pdf/10.1021/ja00049a041 | - |
| heal.journalName | J Am Chem Soc | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1992 | - |
| heal.publisher | American Chemical Society | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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