Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis
Loading...
Date
Authors
Sagoo, G. S.
Tatt, I.
Salanti, G.
Butterworth, A. S.
Sarwar, N.
van Maarle, M.
Jukema, J. W.
Wiman, B.
Kastelein, J. J.
Bennet, A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Am J Epidemiol
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid fractions and CHD risk in population-based cohort, case-control, and cross-sectional studies published by January 2007. Meta-analyses of 22,734 CHD cases and 50,177 controls in 89 association studies focused on the relations of the T-93G (rs1800590), D9N (rs1801177), G188E, N291S (rs268), PvuII (rs285), HindIII (rs320), and S447X (rs328) polymorphisms to high density lipoprotein cholesterol, triglycerides, myocardial infarction, or coronary stenosis. Carriers of 9N or 291S had modestly adverse lipid profiles. Carriers of the less common allele of HindIII or of 447X had modestly advantageous profiles. The combined odds ratio for CHD among carriers was 1.33 (95% confidence interval (CI): 1.14, 1.56) for 9N, 1.07 (95% CI: 0.96, 1.20) for 291S, 0.89 (95% CI: 0.81, 0.98) for the less common HindIII allele, and 0.84 (95% CI: 0.75, 0.94) for 447X. For T-93G (odds ratio (OR) = 1.22, 95% CI: 0.98, 1.52) and PvuII (OR = 0.96, 95% CI: 0.89, 1.04), there were null associations with lipid levels or CHD risk; information on G188E was limited (OR = 2.80, 95% CI: 0.88, 8.87). The study of LPL genotypes confirms the existence of close interrelations between high density lipoprotein cholesterol and triglyceride pathways. The influence of these genotypes on CHD risk warrants further investigation.
Description
Keywords
Alleles, Cholesterol, HDL/blood/genetics, Confidence Intervals, Coronary Disease/blood/enzymology/epidemiology/*genetics, Coronary Stenosis/genetics, Genotype, Great Britain/epidemiology, Humans, Lipids/blood, Lipoprotein Lipase/blood/*genetics, Myocardial Infarction/genetics, Odds Ratio, *Polymorphism, Genetic, Triglycerides/blood/genetics
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/18922999
http://aje.oxfordjournals.org/content/168/11/1233.full.pdf
http://aje.oxfordjournals.org/content/168/11/1233.full.pdf
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής