Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis

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dc.contributor.authorSagoo, G. S.en
dc.contributor.authorTatt, I.en
dc.contributor.authorSalanti, G.en
dc.contributor.authorButterworth, A. S.en
dc.contributor.authorSarwar, N.en
dc.contributor.authorvan Maarle, M.en
dc.contributor.authorJukema, J. W.en
dc.contributor.authorWiman, B.en
dc.contributor.authorKastelein, J. J.en
dc.contributor.authorBennet, A.en
dc.contributor.authorde Faire, U.en
dc.contributor.authorDanesh, J.en
dc.contributor.authorHiggins, J. P.en
dc.date.accessioned2015-11-24T18:51:58Z
dc.date.available2015-11-24T18:51:58Z
dc.identifier.issn1476-6256-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18335
dc.rightsDefault Licence-
dc.subjectAllelesen
dc.subjectCholesterol, HDL/blood/geneticsen
dc.subjectConfidence Intervalsen
dc.subjectCoronary Disease/blood/enzymology/epidemiology/*geneticsen
dc.subjectCoronary Stenosis/geneticsen
dc.subjectGenotypeen
dc.subjectGreat Britain/epidemiologyen
dc.subjectHumansen
dc.subjectLipids/blooden
dc.subjectLipoprotein Lipase/blood/*geneticsen
dc.subjectMyocardial Infarction/geneticsen
dc.subjectOdds Ratioen
dc.subject*Polymorphism, Geneticen
dc.subjectTriglycerides/blood/geneticsen
dc.titleSeven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysisen
heal.abstractLipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid fractions and CHD risk in population-based cohort, case-control, and cross-sectional studies published by January 2007. Meta-analyses of 22,734 CHD cases and 50,177 controls in 89 association studies focused on the relations of the T-93G (rs1800590), D9N (rs1801177), G188E, N291S (rs268), PvuII (rs285), HindIII (rs320), and S447X (rs328) polymorphisms to high density lipoprotein cholesterol, triglycerides, myocardial infarction, or coronary stenosis. Carriers of 9N or 291S had modestly adverse lipid profiles. Carriers of the less common allele of HindIII or of 447X had modestly advantageous profiles. The combined odds ratio for CHD among carriers was 1.33 (95% confidence interval (CI): 1.14, 1.56) for 9N, 1.07 (95% CI: 0.96, 1.20) for 291S, 0.89 (95% CI: 0.81, 0.98) for the less common HindIII allele, and 0.84 (95% CI: 0.75, 0.94) for 447X. For T-93G (odds ratio (OR) = 1.22, 95% CI: 0.98, 1.52) and PvuII (OR = 0.96, 95% CI: 0.89, 1.04), there were null associations with lipid levels or CHD risk; information on G188E was limited (OR = 2.80, 95% CI: 0.88, 8.87). The study of LPL genotypes confirms the existence of close interrelations between high density lipoprotein cholesterol and triglyceride pathways. The influence of these genotypes on CHD risk warrants further investigation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/aje/kwn235-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18922999-
heal.identifier.secondaryhttp://aje.oxfordjournals.org/content/168/11/1233.full.pdf-
heal.journalNameAm J Epidemiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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