Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin
Φόρτωση...
Ημερομηνία
Συγγραφείς
Miura, M.
Morris, G. M.
Micca, P. L.
Lombardo, D. T.
Youngs, K. M.
Kalef-Ezra, J. A.
Hoch, D. A.
Slatkin, D. N.
Ma, R.
Coderre, J. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Radiat Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The first control of a malignant tumor in vivo by porphyrin- mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary carcinomas, boron uptake using a single injection of either p-boronophenylalanine (BPA) or mercaptoundecahydrododecaborane (BSH) was compared with either a single injection or multiple injections of the carboranylporphyrin CuTCPH. The BSH and BPA doses used were comparable to the highest doses of these compounds previously administered in a single injection to rodents. For BNCT, boron concentrations averaged 85 microg (10)B/g in the tumor and 4 microg (10)B/g in blood 2 days after the last of six injections (over 32 h) that delivered a total of 190 microg CuTCPH/g body weight. During a single 15, 20, 25 or 30 MW-min exposure to the thermalized neutron beam of the Brookhaven Medical Research Reactor, a tumor received average absorbed doses of approximately 39, 52, 66 or 79 Gy, respectively. A long-term (>200 days) tumor control rate of 71% was achieved at a dose of 66 Gy with minimal damage to the leg. Equivalent long-term tumor control by a single exposure to 42 Gy X rays was achieved, but with greater damage to the irradiated leg.
Περιγραφή
Λέξεις-κλειδιά
Animals, Borohydrides/pharmacokinetics, Boron/analysis/pharmacokinetics, Boron Compounds/pharmacokinetics, *Boron Neutron Capture Therapy, Drug Carriers, Female, Hindlimb, Hydrophobic and Hydrophilic Interactions, Injections, Intraperitoneal, Mammary Neoplasms, Experimental/*radiotherapy, Mice, Mice, Inbred BALB C, Phenylalanine/*analogs & derivatives/pharmacokinetics, Sulfhydryl Compounds/pharmacokinetics, Thorax, Tissue Distribution
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11260662
http://www.bioone.org/doi/abs/10.1667/0033-7587%282001%29155%5B0603%3ABNCTOA%5D2.0.CO%3B2
http://www.bioone.org/doi/abs/10.1667/0033-7587%282001%29155%5B0603%3ABNCTOA%5D2.0.CO%3B2
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής