Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin

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dc.contributor.authorMiura, M.en
dc.contributor.authorMorris, G. M.en
dc.contributor.authorMicca, P. L.en
dc.contributor.authorLombardo, D. T.en
dc.contributor.authorYoungs, K. M.en
dc.contributor.authorKalef-Ezra, J. A.en
dc.contributor.authorHoch, D. A.en
dc.contributor.authorSlatkin, D. N.en
dc.contributor.authorMa, R.en
dc.contributor.authorCoderre, J. A.en
dc.date.accessioned2015-11-24T19:32:25Z
dc.date.available2015-11-24T19:32:25Z
dc.identifier.issn0033-7587-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23412
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBorohydrides/pharmacokineticsen
dc.subjectBoron/analysis/pharmacokineticsen
dc.subjectBoron Compounds/pharmacokineticsen
dc.subject*Boron Neutron Capture Therapyen
dc.subjectDrug Carriersen
dc.subjectFemaleen
dc.subjectHindlimben
dc.subjectHydrophobic and Hydrophilic Interactionsen
dc.subjectInjections, Intraperitonealen
dc.subjectMammary Neoplasms, Experimental/*radiotherapyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectPhenylalanine/*analogs & derivatives/pharmacokineticsen
dc.subjectSulfhydryl Compounds/pharmacokineticsen
dc.subjectThoraxen
dc.subjectTissue Distributionen
dc.titleBoron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrinen
heal.abstractThe first control of a malignant tumor in vivo by porphyrin- mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary carcinomas, boron uptake using a single injection of either p-boronophenylalanine (BPA) or mercaptoundecahydrododecaborane (BSH) was compared with either a single injection or multiple injections of the carboranylporphyrin CuTCPH. The BSH and BPA doses used were comparable to the highest doses of these compounds previously administered in a single injection to rodents. For BNCT, boron concentrations averaged 85 microg (10)B/g in the tumor and 4 microg (10)B/g in blood 2 days after the last of six injections (over 32 h) that delivered a total of 190 microg CuTCPH/g body weight. During a single 15, 20, 25 or 30 MW-min exposure to the thermalized neutron beam of the Brookhaven Medical Research Reactor, a tumor received average absorbed doses of approximately 39, 52, 66 or 79 Gy, respectively. A long-term (>200 days) tumor control rate of 71% was achieved at a dose of 66 Gy with minimal damage to the leg. Equivalent long-term tumor control by a single exposure to 42 Gy X rays was achieved, but with greater damage to the irradiated leg.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11260662-
heal.identifier.secondaryhttp://www.bioone.org/doi/abs/10.1667/0033-7587%282001%29155%5B0603%3ABNCTOA%5D2.0.CO%3B2-
heal.journalNameRadiat Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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