Endothelin system and atrial fibrillation post-cardiac surgery
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Date
Authors
Kolettis, T. M.
Kyriakides, Z. S.
Zygalaki, E.
Kyrzopoulos, S.
Kaklamanis, L.
Nikolaou, N.
Lianidou, E. S.
Kremastinos, D. T.
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Abstract
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peer-reviewed
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Journal name
J Interv Card Electrophysiol
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Description
OBJECTIVE: We investigated the relation between the endothelin system and atrial fibrillation. BACKGROUND: Endothelin has been implicated in the pathophysiology of atrial fibrillation, but the exact role of A- and B-receptors is unknown. METHODS: We obtained right atrial biopsies from patients in sinus rhythm and preserved left ventricular function, undergoing off-pump coronary artery bypass grafting. The expression of endothelin, A- and B-receptors was measured using real time reverse-transcribed polymerase chain reaction. RESULTS: We studied 52 patients (45 male, mean age 66+/-1 years, mean ejection fraction 52+/-1%). During a 5-day post-operative period, persistent atrial fibrillation occurred in 15 patients (28.8%). Endothelin mRNA expression was comparable in patients who subsequently developed atrial fibrillation and in those maintaining sinus rhythm. However, the former group displayed down-regulation of endothelin A- (by approximately 60%, p=0.0059) and of B-receptors (by approximately 40%, p=0.0084). The decreased endothelin A-receptor expression could predict atrial fibrillation occurrence (Wilks lambda=0.86, F=6.16, p=0.017). CONCLUSION: Decreased endothelin A- and B-receptor expression is associated with atrial fibrillation after bypass surgery.
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Keywords
Aged, Atrial Fibrillation/*physiopathology, Biopsy, Chi-Square Distribution, Coronary Artery Bypass, Off-Pump, Endothelins/*metabolism, Female, Humans, Male, Predictive Value of Tests, RNA, Messenger/metabolism, ROC Curve, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Statistics, Nonparametric
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Citation
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http://www.ncbi.nlm.nih.gov/pubmed/18264746
http://www.springerlink.com/content/ul182235u7680257/fulltext.pdf
http://www.springerlink.com/content/ul182235u7680257/fulltext.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής