Endothelin system and atrial fibrillation post-cardiac surgery

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dc.contributor.authorKolettis, T. M.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorZygalaki, E.en
dc.contributor.authorKyrzopoulos, S.en
dc.contributor.authorKaklamanis, L.en
dc.contributor.authorNikolaou, N.en
dc.contributor.authorLianidou, E. S.en
dc.contributor.authorKremastinos, D. T.en
dc.date.accessioned2015-11-24T19:19:29Z
dc.date.available2015-11-24T19:19:29Z
dc.identifier.issn1383-875X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21964
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAtrial Fibrillation/*physiopathologyen
dc.subjectBiopsyen
dc.subjectChi-Square Distributionen
dc.subjectCoronary Artery Bypass, Off-Pumpen
dc.subjectEndothelins/*metabolismen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPredictive Value of Testsen
dc.subjectRNA, Messenger/metabolismen
dc.subjectROC Curveen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectSensitivity and Specificityen
dc.subjectStatistics, Nonparametricen
dc.titleEndothelin system and atrial fibrillation post-cardiac surgeryen
heal.abstractOBJECTIVE: We investigated the relation between the endothelin system and atrial fibrillation. BACKGROUND: Endothelin has been implicated in the pathophysiology of atrial fibrillation, but the exact role of A- and B-receptors is unknown. METHODS: We obtained right atrial biopsies from patients in sinus rhythm and preserved left ventricular function, undergoing off-pump coronary artery bypass grafting. The expression of endothelin, A- and B-receptors was measured using real time reverse-transcribed polymerase chain reaction. RESULTS: We studied 52 patients (45 male, mean age 66+/-1 years, mean ejection fraction 52+/-1%). During a 5-day post-operative period, persistent atrial fibrillation occurred in 15 patients (28.8%). Endothelin mRNA expression was comparable in patients who subsequently developed atrial fibrillation and in those maintaining sinus rhythm. However, the former group displayed down-regulation of endothelin A- (by approximately 60%, p=0.0059) and of B-receptors (by approximately 40%, p=0.0084). The decreased endothelin A-receptor expression could predict atrial fibrillation occurrence (Wilks lambda=0.86, F=6.16, p=0.017). CONCLUSION: Decreased endothelin A- and B-receptor expression is associated with atrial fibrillation after bypass surgery.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s10840-008-9206-5-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18264746-
heal.identifier.secondaryhttp://www.springerlink.com/content/ul182235u7680257/fulltext.pdf-
heal.journalNameJ Interv Card Electrophysiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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