Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos
Φόρτωση...
Ημερομηνία
Συγγραφείς
Karcz-Kubicha, M.
Quarta, D.
Hope, B. T.
Antoniou, K.
Muller, C. E.
Morales, M.
Schindler, C. W.
Goldberg, S. R.
Ferre, S.
Τίτλος Εφημερίδας
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Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Neurosci
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
When striatal neurons are strongly activated they produce adenosine, which activates nearby adenosine A1 receptors (A1Rs) and adenosine A2A receptors (A2ARs). Although the effects of A1R or A2AR activation on neural activity in the striatum have been examined separately, the effects of coactivating both receptors has not been investigated. Using c-Fos immunohistochemistry as an indicator of neural activity, we examined the effects of coactivation of A1Rs and A2ARs on neural activity and their mechanism of interaction in the caudate-putamen, nucleus accumbens (NAc) and prefrontal cortex in rats. Administration of a motor-depressant dose of the A2AR agonist CGS 21680 (0.5 mg/kg i.p.) did not significantly induce c-fos expression in any of these brain regions. Administration of a motor-depressant dose of the A1R agonist CPA (0.3 mg/kg, i.p.) produced a small but significant induction of c-fos expression only in the shell of the NAc. Coadministration of CGS 21680 and CPA produced a synergistic induction of c-fos expression in the caudate-putamen, cingulate cortex, and especially the NAc. In the shell of the NAc administration of CPA significantly decreased extracellular dopamine levels measured by in vivo microdialysis and blocked CGS 21680-induced increases in dopamine levels. Because it has been previously shown that activation of dopamine D2 receptors (D2Rs) by endogenous dopamine blocks A2AR-mediated c-fos expression, it is hypothesized that the enabling role of A1Rs in A2AR-mediated striatal c-fos expression is related to the A1R-mediated inhibition of dopamine release.
Περιγραφή
Λέξεις-κλειδιά
Adenosine/*analogs & derivatives/pharmacology, Animals, Brain Chemistry/drug effects, Corpus Striatum/*metabolism, Dopamine/analysis, Drug Synergism, Immunohistochemistry, Male, Microdialysis, Neurons/*metabolism, Phenethylamines/pharmacology, Proto-Oncogene Proteins c-fos/*biosynthesis/drug effects, Purinergic P1 Receptor Agonists, Rats, Rats, Sprague-Dawley, Receptor, Adenosine A2A, Receptors, Purinergic P1/*metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12887411
http://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54bvl&s=c1d62d089a8b3f0636ade61005f5240f5f000018
http://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54i1l&s=967cbc7e9d8d8557d911d18a64438a58b52ba2d4
http://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54bvl&s=c1d62d089a8b3f0636ade61005f5240f5f000018
http://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54i1l&s=967cbc7e9d8d8557d911d18a64438a58b52ba2d4
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Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής