Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos

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dc.contributor.authorKarcz-Kubicha, M.en
dc.contributor.authorQuarta, D.en
dc.contributor.authorHope, B. T.en
dc.contributor.authorAntoniou, K.en
dc.contributor.authorMuller, C. E.en
dc.contributor.authorMorales, M.en
dc.contributor.authorSchindler, C. W.en
dc.contributor.authorGoldberg, S. R.en
dc.contributor.authorFerre, S.en
dc.date.accessioned2015-11-24T19:19:51Z
dc.date.available2015-11-24T19:19:51Z
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21990
dc.rightsDefault Licence-
dc.subjectAdenosine/*analogs & derivatives/pharmacologyen
dc.subjectAnimalsen
dc.subjectBrain Chemistry/drug effectsen
dc.subjectCorpus Striatum/*metabolismen
dc.subjectDopamine/analysisen
dc.subjectDrug Synergismen
dc.subjectImmunohistochemistryen
dc.subjectMaleen
dc.subjectMicrodialysisen
dc.subjectNeurons/*metabolismen
dc.subjectPhenethylamines/pharmacologyen
dc.subjectProto-Oncogene Proteins c-fos/*biosynthesis/drug effectsen
dc.subjectPurinergic P1 Receptor Agonistsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptor, Adenosine A2Aen
dc.subjectReceptors, Purinergic P1/*metabolismen
dc.titleEnabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fosen
heal.abstractWhen striatal neurons are strongly activated they produce adenosine, which activates nearby adenosine A1 receptors (A1Rs) and adenosine A2A receptors (A2ARs). Although the effects of A1R or A2AR activation on neural activity in the striatum have been examined separately, the effects of coactivating both receptors has not been investigated. Using c-Fos immunohistochemistry as an indicator of neural activity, we examined the effects of coactivation of A1Rs and A2ARs on neural activity and their mechanism of interaction in the caudate-putamen, nucleus accumbens (NAc) and prefrontal cortex in rats. Administration of a motor-depressant dose of the A2AR agonist CGS 21680 (0.5 mg/kg i.p.) did not significantly induce c-fos expression in any of these brain regions. Administration of a motor-depressant dose of the A1R agonist CPA (0.3 mg/kg, i.p.) produced a small but significant induction of c-fos expression only in the shell of the NAc. Coadministration of CGS 21680 and CPA produced a synergistic induction of c-fos expression in the caudate-putamen, cingulate cortex, and especially the NAc. In the shell of the NAc administration of CPA significantly decreased extracellular dopamine levels measured by in vivo microdialysis and blocked CGS 21680-induced increases in dopamine levels. Because it has been previously shown that activation of dopamine D2 receptors (D2Rs) by endogenous dopamine blocks A2AR-mediated c-fos expression, it is hypothesized that the enabling role of A1Rs in A2AR-mediated striatal c-fos expression is related to the A1R-mediated inhibition of dopamine release.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12887411-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54bvl&s=c1d62d089a8b3f0636ade61005f5240f5f000018-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1046/j.1460-9568.2003.02747.x/asset/j.1460-9568.2003.02747.x.pdf?v=1&t=h0c54i1l&s=967cbc7e9d8d8557d911d18a64438a58b52ba2d4-
heal.journalNameEur J Neuroscien
heal.journalTypepeer-reviewed-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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