Persistence of an atherogenic lipid profile after treatment of acute infection with brucella
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Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
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Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Lipid Research
Όνομα βιβλίου
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Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Serum lipid changes during infection may be associated with atherogenesis. No data are available on the effect of Brucellosis on lipids. Lipid parameters were determined in 28 patients with Brucellosis on admission and 4 months following treatment and were compared with 24 matched controls. Fasting levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) A, B, E CII, and CIII, and oxidized LDL (oxLDL) were measured. Activities of serum cholesterol ester transfer protein (CETP), paraoxonase 1 (PON1), and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and levels of cytokines [interleukins (IL)-1 beta, IL-6, and tumor necrosis factor (TNFa)] were also determined. On admission, patients compared with controls had 1) lower levels of TC, HDL-C, LDL-cholesterol (LDL-C), ApoB, ApoAI, and ApoCIII and higher LDL-C/HDL-C and ApoB/ApoAI ratios; 2) higher levels of IL-1b, IL-6, and TNFa; 3) similar ApoCII and oxLDL levels and Lp-PLA(2) activity, lower PON1, and higher CETP activity; and 4) higher small dense LDL-C concentration. Four months later, increases in TC, HDL-C, LDL-C, ApoB, ApoAI, and ApoCIII levels, ApoB/ApoAI ratio, and PON1 activity were noticed compared with baseline, whereas CETP activity decreased. LDL-C/HDL-C ratio, ApoCII, and oxLDL levels, Lp-PLA(2) activity, and small dense LDL-C concentration were not altered. Brucella infection is associated with an atherogenic lipid profile that is not fully restored 4 months following treatment.-Apostolou, F., I. F. Gazi, A. Kostoula, C. C. Tellis, A. D. Tselepis, M. Elisaf, and E. N. Liberopoulos. Persistence of an atherogenic lipid profile after treatment of acute infection with brucella. J. Lipid Res. 2009. 50: 2532-2539.
Περιγραφή
Λέξεις-κλειδιά
small dense low density lipoprotein, cytokines, lipoprotein-associated phospholipase a(2), paraoxonase 1, cholesterol ester transfer protein, oxidized low density lipoprotein, platelet-activating-factor, low-density-lipoprotein, coronary-heart-disease, acute-phase response, immunodeficiency-virus-infection, systemic inflammatory response, serum paraoxonase-1 activity, ii phospholipase a(2), factor-acetylhydrolase, helicobacter-pylori
Θεματική κατηγορία
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Σύνδεσμος
<Go to ISI>://000271769000020
http://www.jlr.org/content/50/12/2532.full.pdf
http://www.jlr.org/content/50/12/2532.full.pdf
Γλώσσα
en
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Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας