Persistence of an atherogenic lipid profile after treatment of acute infection with brucella

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dc.contributor.authorApostolou, F.en
dc.contributor.authorGazi, I. F.en
dc.contributor.authorKostoula, A.en
dc.contributor.authorTellis, C. C.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorLiberopoulos, E. N.en
dc.date.accessioned2015-11-24T16:44:17Z
dc.date.available2015-11-24T16:44:17Z
dc.identifier.issn0022-2275-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8787
dc.rightsDefault Licence-
dc.subjectsmall dense low density lipoproteinen
dc.subjectcytokinesen
dc.subjectlipoprotein-associated phospholipase a(2)en
dc.subjectparaoxonase 1en
dc.subjectcholesterol ester transfer proteinen
dc.subjectoxidized low density lipoproteinen
dc.subjectplatelet-activating-factoren
dc.subjectlow-density-lipoproteinen
dc.subjectcoronary-heart-diseaseen
dc.subjectacute-phase responseen
dc.subjectimmunodeficiency-virus-infectionen
dc.subjectsystemic inflammatory responseen
dc.subjectserum paraoxonase-1 activityen
dc.subjectii phospholipase a(2)en
dc.subjectfactor-acetylhydrolaseen
dc.subjecthelicobacter-pylorien
dc.titlePersistence of an atherogenic lipid profile after treatment of acute infection with brucellaen
heal.abstractSerum lipid changes during infection may be associated with atherogenesis. No data are available on the effect of Brucellosis on lipids. Lipid parameters were determined in 28 patients with Brucellosis on admission and 4 months following treatment and were compared with 24 matched controls. Fasting levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) A, B, E CII, and CIII, and oxidized LDL (oxLDL) were measured. Activities of serum cholesterol ester transfer protein (CETP), paraoxonase 1 (PON1), and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and levels of cytokines [interleukins (IL)-1 beta, IL-6, and tumor necrosis factor (TNFa)] were also determined. On admission, patients compared with controls had 1) lower levels of TC, HDL-C, LDL-cholesterol (LDL-C), ApoB, ApoAI, and ApoCIII and higher LDL-C/HDL-C and ApoB/ApoAI ratios; 2) higher levels of IL-1b, IL-6, and TNFa; 3) similar ApoCII and oxLDL levels and Lp-PLA(2) activity, lower PON1, and higher CETP activity; and 4) higher small dense LDL-C concentration. Four months later, increases in TC, HDL-C, LDL-C, ApoB, ApoAI, and ApoCIII levels, ApoB/ApoAI ratio, and PON1 activity were noticed compared with baseline, whereas CETP activity decreased. LDL-C/HDL-C ratio, ApoCII, and oxLDL levels, Lp-PLA(2) activity, and small dense LDL-C concentration were not altered. Brucella infection is associated with an atherogenic lipid profile that is not fully restored 4 months following treatment.-Apostolou, F., I. F. Gazi, A. Kostoula, C. C. Tellis, A. D. Tselepis, M. Elisaf, and E. N. Liberopoulos. Persistence of an atherogenic lipid profile after treatment of acute infection with brucella. J. Lipid Res. 2009. 50: 2532-2539.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1194/jlr.P900063-JLR200-
heal.identifier.secondary<Go to ISI>://000271769000020-
heal.identifier.secondaryhttp://www.jlr.org/content/50/12/2532.full.pdf-
heal.journalNameJournal of Lipid Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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