Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases
Φόρτωση...
Ημερομηνία
Συγγραφείς
Voulgaris, E.
Pentheroudakis, G.
Pappa, L.
Bafa, M.
Goussia, A.
Dalezis, P.
Tsombanidou, C.
Geromichalos, G.
Papageorgiou, A.
Koutsilieris, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Lung Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. PATIENTS AND METHODS: 150 patients with small (SCLC) and non-small cell lung cancer (NSCLC) of all stages and 3 control groups were prospectively studied. Immunocytochemical study (cytokeratins 7-20, TTF1) in all positive urine specimens and chemokine profile (CXCR4, CCL21) study of the primary tumor in selected positive patients was performed. In experimental study, C57Bl/6 BALB/C mice injected with LLC lung and 4T1 mammary cancer cells were used for the detection of positive urine cytology. RESULTS: 11% of patients with NSCLC, 7% of patients with SCLC and none of the control group had positive urine cytology. In NSCLC, metastatic disease and high tumor burden positively correlated (p=0.01 and 0.03 respectively) with the phenomenon. In SCLC, correlation with extensive disease and multiple metastatic sites (p=0.02 and 0.04 respectively) was found. No correlation was found in either group with: age, gender, histology, performance status, line of chemotherapy, previous platinum-based chemotherapy, adrenal metastases, renal function, abnormal urinary sediment, response to chemotherapy and overall survival (p=0.9). Distinctive chemokine expression was identified in positive patients studied and was not observed in negative patients (x2 p=0.008). In the experimental study, only the LLC lung cancer cells were detected in the urine cytology of mice. CONCLUSION: This phenomenon, carrying undefined pathophysiological mechanisms, seems to characterize only patients with metastatic/extensive disease and high tumor burden. Further studies are needed to validate our preliminary chemokine expression results.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Animals, Carcinoma, Lewis Lung/pathology/urine, Carcinoma, Non-Small-Cell Lung/metabolism/mortality/pathology/*urine, Case-Control Studies, Chemokine CCL21/metabolism, Female, Humans, Lung Neoplasms/metabolism/mortality/pathology/*urine, Male, Mammary Neoplasms, Experimental/pathology/urine, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Middle Aged, Neoplasm Staging, Neoplasm Transplantation, Receptors, CXCR4/metabolism, Small Cell Lung Carcinoma/metabolism/mortality/pathology/*urine, Transplantation, Heterologous, Urologic Neoplasms/secondary
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21111510
http://ac.els-cdn.com/S0169500210005234/1-s2.0-S0169500210005234-main.pdf?_tid=d323b48f080bc78cce802aceca649a65&acdnat=1333955181_d0a27d0c3fcf0cf450709a7e4d5c372b
http://ac.els-cdn.com/S0169500210005234/1-s2.0-S0169500210005234-main.pdf?_tid=d323b48f080bc78cce802aceca649a65&acdnat=1333955181_d0a27d0c3fcf0cf450709a7e4d5c372b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής