Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases

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dc.contributor.authorVoulgaris, E.en
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorPappa, L.en
dc.contributor.authorBafa, M.en
dc.contributor.authorGoussia, A.en
dc.contributor.authorDalezis, P.en
dc.contributor.authorTsombanidou, C.en
dc.contributor.authorGeromichalos, G.en
dc.contributor.authorPapageorgiou, A.en
dc.contributor.authorKoutsilieris, M.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T18:57:51Z
dc.date.available2015-11-24T18:57:51Z
dc.identifier.issn1872-8332-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19215
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAnimalsen
dc.subjectCarcinoma, Lewis Lung/pathology/urineen
dc.subjectCarcinoma, Non-Small-Cell Lung/metabolism/mortality/pathology/*urineen
dc.subjectCase-Control Studiesen
dc.subjectChemokine CCL21/metabolismen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLung Neoplasms/metabolism/mortality/pathology/*urineen
dc.subjectMaleen
dc.subjectMammary Neoplasms, Experimental/pathology/urineen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Inbred C57BLen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectNeoplasm Transplantationen
dc.subjectReceptors, CXCR4/metabolismen
dc.subjectSmall Cell Lung Carcinoma/metabolism/mortality/pathology/*urineen
dc.subjectTransplantation, Heterologousen
dc.subjectUrologic Neoplasms/secondaryen
dc.titlePositive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastasesen
heal.abstractPURPOSE: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. PATIENTS AND METHODS: 150 patients with small (SCLC) and non-small cell lung cancer (NSCLC) of all stages and 3 control groups were prospectively studied. Immunocytochemical study (cytokeratins 7-20, TTF1) in all positive urine specimens and chemokine profile (CXCR4, CCL21) study of the primary tumor in selected positive patients was performed. In experimental study, C57Bl/6 BALB/C mice injected with LLC lung and 4T1 mammary cancer cells were used for the detection of positive urine cytology. RESULTS: 11% of patients with NSCLC, 7% of patients with SCLC and none of the control group had positive urine cytology. In NSCLC, metastatic disease and high tumor burden positively correlated (p=0.01 and 0.03 respectively) with the phenomenon. In SCLC, correlation with extensive disease and multiple metastatic sites (p=0.02 and 0.04 respectively) was found. No correlation was found in either group with: age, gender, histology, performance status, line of chemotherapy, previous platinum-based chemotherapy, adrenal metastases, renal function, abnormal urinary sediment, response to chemotherapy and overall survival (p=0.9). Distinctive chemokine expression was identified in positive patients studied and was not observed in negative patients (x2 p=0.008). In the experimental study, only the LLC lung cancer cells were detected in the urine cytology of mice. CONCLUSION: This phenomenon, carrying undefined pathophysiological mechanisms, seems to characterize only patients with metastatic/extensive disease and high tumor burden. Further studies are needed to validate our preliminary chemokine expression results.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.lungcan.2010.10.018-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21111510-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0169500210005234/1-s2.0-S0169500210005234-main.pdf?_tid=d323b48f080bc78cce802aceca649a65&acdnat=1333955181_d0a27d0c3fcf0cf450709a7e4d5c372b-
heal.journalNameLung Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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