Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes
| dc.contributor.author | Katritsis, D. G. | en |
| dc.contributor.author | Siontis, G. C. | en |
| dc.contributor.author | Kastrati, A. | en |
| dc.contributor.author | van't Hof, A. W. | en |
| dc.contributor.author | Neumann, F. J. | en |
| dc.contributor.author | Siontis, K. C. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:00:47Z | |
| dc.date.available | 2015-11-24T19:00:47Z | |
| dc.identifier.issn | 1522-9645 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19594 | |
| dc.rights | Default Licence | - |
| dc.subject | Acute Coronary Syndrome/*radiography | en |
| dc.subject | Aged | en |
| dc.subject | Coronary Angiography/*methods | en |
| dc.subject | Early Diagnosis | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Length of Stay | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Prognosis | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Recurrence | en |
| dc.subject | Risk Factors | en |
| dc.subject | Time Factors | en |
| dc.title | Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes | en |
| heal.abstract | AIMS: An invasive approach is superior to medical management for the treatment of patients with acute coronary syndromes without ST-segment elevation (NSTE-ACS), but the optimal timing of coronary angiography and subsequent intervention, if indicated, has not been settled. METHODS AND RESULTS: We conducted a meta-analysis of randomized trials addressing the optimal timing (early vs. delayed) of coronary angiography in NSTE-ACS. Four trials with 4013 patients were eligible (ABOARD, ELISA, ISAR-COOL, TIMACS), and data for longer follow-up periods than those published became available for this meta-analysis by the ELISA and ISAR-COOL investigators. The median time from admission or randomization to coronary angiography ranged from 1.16 to 14 h in the early and 20.8-86 h in the delayed strategy group. No statistically significant difference of risk of death [random effects risk ratio (RR) 0.85, 95% confidence interval (CI) 0.64-1.11] or myocardial infarction (MI) (RR 0.94, 95% CI 0.61-1.45) was detected between the two strategies. Early intervention significantly reduced the risk for recurrent ischaemia (RR 0.59, 95% CI 0.38-0.92, P = 0.02) and the duration of hospital stay (by 28%, 95% CI 22-35%, P < 0.001). Furthermore, decreased major bleeding events (RR 0.78, 95% CI 0.57-1.07, P = 0.13), and less major events (death, MI, or stroke) (RR 0.91, 95% CI 0.82-1.01, P = 0.09) were observed with the early strategy but these differences were not nominally significant. CONCLUSION: Early coronary angiography and potential intervention reduces the risk of recurrent ischaemia, and shortens hospital stay in patients with NSTE-ACS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/eurheartj/ehq276 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20709722 | - |
| heal.identifier.secondary | http://eurheartj.oxfordjournals.org/content/32/1/32.full.pdf | - |
| heal.journalName | Eur Heart J | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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