Changes in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycle
Φόρτωση...
Ημερομηνία
Συγγραφείς
Messinis, I. E.
Koutsoyiannis, D.
Milingos, S.
Tsahalina, E.
Seferiadis, K.
Lolis, D.
Templeton, A. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Endocrinol (Oxf)
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: We studied changes in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycle. DESIGN: Normally cycling women were investigated during two consecutive menstrual cycles. In each woman, GnRH tests were performed during the two LH surges and several times during the luteal-follicular transition. Data for analysis were available in all women on days -8, -6, -4, -2, -1, 1, 2, 3, 4, 5 and 7 in relation to the onset of second menstruation (day 1). PATIENTS: Five normally ovulating parous women were studied. MEASUREMENTS: Pituitary response to GnRH was calculated as the net increase in LH and FSH at 30 minutes (delta LH and delta FSH) above the basal value. RESULTS: delta LH and delta FSH showed a similar pattern of significant changes during the luteal-follicular transition. They decreased progressively from days -8 to 1 and increased on day 2. delta LH and delta FSH then decreased on days 3 and 4 and showed a further increase on days 5 and 7. In contrast to these changes, basal FSH levels increased from days -2 to 1 and remained high up to day 5, while basal LH levels showed a trend to increase only after the onset of menses. CONCLUSIONS: These results demonstrate that the increase in basal FSH secretion during the luteal-follicular transition is GnRH independent. It is suggested that LH and FSH release under the stimulation by GnRH is regulated by a common mechanism.
Περιγραφή
Λέξεις-κλειδιά
Adult, Female, Follicle Stimulating Hormone/*secretion, Growth Hormone-Releasing Hormone/*pharmacology, Humans, Luteinizing Hormone/*secretion, Menstrual Cycle/*metabolism, Pituitary Gland/drug effects/*secretion, Stimulation, Chemical
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8435896
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1993.tb00988.x/asset/j.1365-2265.1993.tb00988.x.pdf?v=1&t=h2d2zi1e&s=8f1f5197cec7922f408061a25a28f3fdaf65ad1c
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1993.tb00988.x/asset/j.1365-2265.1993.tb00988.x.pdf?v=1&t=h2d2zi1e&s=8f1f5197cec7922f408061a25a28f3fdaf65ad1c
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής