Changes in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycle

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dc.contributor.authorMessinis, I. E.en
dc.contributor.authorKoutsoyiannis, D.en
dc.contributor.authorMilingos, S.en
dc.contributor.authorTsahalina, E.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorLolis, D.en
dc.contributor.authorTempleton, A. A.en
dc.date.accessioned2015-11-24T19:31:03Z
dc.date.available2015-11-24T19:31:03Z
dc.identifier.issn0300-0664-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23197
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectFollicle Stimulating Hormone/*secretionen
dc.subjectGrowth Hormone-Releasing Hormone/*pharmacologyen
dc.subjectHumansen
dc.subjectLuteinizing Hormone/*secretionen
dc.subjectMenstrual Cycle/*metabolismen
dc.subjectPituitary Gland/drug effects/*secretionen
dc.subjectStimulation, Chemicalen
dc.titleChanges in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycleen
heal.abstractOBJECTIVE: We studied changes in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycle. DESIGN: Normally cycling women were investigated during two consecutive menstrual cycles. In each woman, GnRH tests were performed during the two LH surges and several times during the luteal-follicular transition. Data for analysis were available in all women on days -8, -6, -4, -2, -1, 1, 2, 3, 4, 5 and 7 in relation to the onset of second menstruation (day 1). PATIENTS: Five normally ovulating parous women were studied. MEASUREMENTS: Pituitary response to GnRH was calculated as the net increase in LH and FSH at 30 minutes (delta LH and delta FSH) above the basal value. RESULTS: delta LH and delta FSH showed a similar pattern of significant changes during the luteal-follicular transition. They decreased progressively from days -8 to 1 and increased on day 2. delta LH and delta FSH then decreased on days 3 and 4 and showed a further increase on days 5 and 7. In contrast to these changes, basal FSH levels increased from days -2 to 1 and remained high up to day 5, while basal LH levels showed a trend to increase only after the onset of menses. CONCLUSIONS: These results demonstrate that the increase in basal FSH secretion during the luteal-follicular transition is GnRH independent. It is suggested that LH and FSH release under the stimulation by GnRH is regulated by a common mechanism.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8435896-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1993.tb00988.x/asset/j.1365-2265.1993.tb00988.x.pdf?v=1&t=h2d2zi1e&s=8f1f5197cec7922f408061a25a28f3fdaf65ad1c-
heal.journalNameClin Endocrinol (Oxf)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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